Results 11 to 20 of about 81,076 (308)

Janus kinase inhibitors: jackpot or potluck?

Oncology Reviews, 2012
The reports of a unique mutation in the Janus kinase-2 gene (JAK2) in polycythemia vera by several independent groups in 2005 quickly spurred the development of the Janus kinase inhibitors.
Pavithran Keechilat, Shripad Brahmanand Pande   +1 more
doaj   +3 more sources

Treatment response to Janus kinase inhibitor in a child affected by Aicardi‐Goutières syndrome [PDF]

Clinical Case Reports, 2023
Key Clinical Message Baricitinib, a Janus kinase inhibitor (JAK‐inhibitor), seems to contribute to an improvement of a child affected by Aicardi‐Goutières syndrome (AGS), reducing the interferon score and determining a recovery of cognitive ...
Jessica Galli, Marco Cattalini, Erika Loi, Rosalba Monica Ferraro, Silvia Giliani, Simona Orcesi, Lorenzo Pinelli, Raffaele Badolato, Elisa Fazzi   +8 more
doaj   +2 more sources

The Upadacitinib - New Janus Kinase Inhibitor - Literature Review

Quality in Sport
Atopic dermatitis (AD) is a chronic, recurrent dermatosis that affects an increasing percentage of the population. It usually affects children and resolves spontaneously, however, symptoms can persist into adulthood and even appear de novo later in life.
Michalina Grzelka, Jakub Plizga, Agnieszka Głuszczyk, Aleksandra Makłowicz, Ewelina Kopczyńska, Angelika Szpulak, Agata Frańczuk, Julia Głoskowska, Katarzyna Kuleta, Patrycja Karkos   +9 more
doaj   +2 more sources

Janus kinase inhibitor audit [PDF]

Clin Med (Lond), 2023
Beck J, Banford S.
europepmc   +3 more sources

Janus Kinase Inhibitors and Cell Therapy [PDF]

Frontiers in Immunology, 2021
Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These therapies are also associated with inflammatory conditions such as graft-versus-host disease (GVHD) and ...
Amer Assal, Markus Y. Mapara, Markus Y. Mapara   +2 more
openaire   +3 more sources

Understanding the efficacy of individual Janus kinase inhibitors in the treatment of ulcerative colitis for future positioning in inflammatory bowel disease treatment

Immunological Medicine, 2023
Recent studies have gradually elucidated the pathogenesis of inflammatory bowel disease; thus, the Janus kinase (JAK)-signal transducers and activators of transcription pathway are strongly involved in the pathophysiology of inflammatory bowel disease ...
Hiroshi Nakase
doaj   +1 more source

JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]

, 2016
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana, De Schepper, Sofie, Desmet, Eline, Lambert, Jo, Speeckaert, Reinhart, Van Gele, Mireille   +5 more
core   +11 more sources

The use of Tofacitinib in the treatment of inflammatory bowel disease [PDF]

Терапевтический архив, 2019
Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus ...
E L Nasonov, D I Abdulganieva, I F Fairushina   +2 more
doaj   +1 more source

Peripheral neuropathy associated with tofacitinib use in alopecia universalis

Journal of Dermatology and Dermatologic Surgery, 2022
Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. Alopecia universalis (AU) is the advanced form of AA characterized by complete scalp and body hair loss.
Raghad Alharthi, Fatimah Alowirdi, Saba Alsuhaymi, Mohammed AlQahtani, Afaf Alsheikh   +4 more
doaj   +1 more source

Refractory mogamulizumab-associated rash responding to an oral Janus kinase inhibitor [PDF]

JAAD Case Reports, 2023
Carine M. Lama, MS, Miguel A. Hernandez-Rovira, BSc, Neha Mehta-Shah, MD, Aaron Russell, MD, Amy C.M. Musiek, MD   +4 more
doaj   +2 more sources