Results 81 to 90 of about 73,039 (208)

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection [PDF]

, 2016
Mutations in genes encoding components of the immune system cause primary immunodeficiencies. Here, we study a patient with recurrent atypical mycobacterial infection and early-onset metastatic bladder carcinoma.
Angulo, I, Burns, SO, Curtis, J, Daza-Cajigal, V, Doffinger, R, Eletto, D, Gaspar, M, Gilmour, KC, Henriquez, F, Kumararatne, D, Nejentsev, S, Nowak, K, Plagnol, V, Thrasher, AJ   +13 more
core   +2 more sources

Negative patch test findings after initiation of upadacitinib: A case report

SAGE Open Medical Case Reports
Upadacitinib is a systemic Janus kinase inhibitor currently approved for the treatment of atopic dermatitis. Many patients with atopic dermatitis have a concomitant diagnosis of allergic contact dermatitis.
Meghan L McPhie, Melanie D Pratt, Mark G Kirchhof   +2 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Successful treatment of the dupilumab-induced psoriatic dermatitis/arthritis and atopic dermatitis with a JAK inhibitor: A case report and literature review

Journal of Allergy and Clinical Immunology: Global
Dupilumab-induced psoriatic dermatitis and arthritis in a patient with atopic dermatitis were effectively managed with upadacitinib, highlighting the use of Janus kinase inhibitors as a possible treatment for biologic therapy side effects.
Misuzu Tsunoda, MD, Takeya Adachi, MD, PhD, Yuuri Nakajima, MD, Yoshihiro Yatomi, MD, Tomoko Shimizu, MD, PhD, Katsuki Nakasute, MD   +5 more
doaj   +1 more source

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia [PDF]

, 2017
JAK2 abnormalities may serve as target for precision medicines in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In the current study we performed a screening for JAK2 mutations and translocations, analyzed the clinical outcome and ...
Besselink, N. (Nicolle), Boer, J.M. (Judith), Boer, M.L. (Monique) den, Boeree, A. (Aurélie), de Goffau-Nobel, W. (Willemieke), de Groot-Kruseman, H.A. (Hester A.), Hoogkamer, A.Q. (Alex Q.), Horstmann, M.A. (Martin), Jerchel, I.S. (Isabel S.), Koudijs, M.J. (Marco J.), Pieters, R. (Rob), Steeghs, E.M.P. (Elisabeth M.P.), van de Ven, C. (Cesca), Zwaan, C.M. (Michel)   +13 more
core   +1 more source

Subcutaneous immunotherapy in a patient taking ofatumumab for multiple sclerosis and upadacitinib for atopic dermatitis

Journal of Allergy and Clinical Immunology: Global
Allergen-specific immunotherapy has not been well-studied in the setting of increasingly common immune system-targeting medications. Subcutaneous immunotherapy may not be contraindicated in patients taking anti-CD20 mAbs antibodies and/or Janus kinase ...
Twan Sia, BA, Leeon Bacchus, BA, Stanley Liu, BS, John Leung, MD   +3 more
doaj   +1 more source

Upadacitinib - New Janus Kinase Inhibitor - Literature Review

Quality in Sport
Atopic dermatitis (AD) is a chronic, recurrent dermatosis that affects an increasing percentage of the population. It usually affects children and resolves spontaneously, however, symptoms can persist into adulthood and even appear de novo later in life. The skin lesions that appear in this disease significantly reduce patients quality of life.
Michalina Grzelka, Jakub Plizga, Agnieszka Głuszczyk, Aleksandra Makłowicz, Ewelina Kopczyńska, Angelika Szpulak, Agata Frańczuk, Julia Głoskowska, Katarzyna Kuleta, Patrycja Karkos   +9 more
openaire   +2 more sources

From concept to practice: real-world safety of JAK inhibitors in rheumatoid arthritis treatment

Frontiers in Medicine
Janus kinase inhibitors have emerged as highly effective therapies, gaining a prominent role in rheumatoid arthritis treatment. However, by inhibiting multiple cytokine effector pathways, these agents have also raised concerns regarding their safety ...
Karina R. Bonfiglioli
doaj   +1 more source