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JC virus in human glial-derived tumors

Human Pathology, 2000
To investigate the presence and the role of polyomaviruses JC (JCV), BK (BKV), and the simian polyomavirus (SV40) in human brain tumors, samples from 25 glial-derived tumors (10 astrocytomas, 5 ependymomas, 5 oligodendrogliomas, and 5 glioblastomas) were examined by means of molecular biology and immunohistochemistry.
R, Caldarelli-Stefano   +5 more
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No association of JC virus with Alzheimer's disease or astrocytomas

Clinical and Diagnostic Virology, 1995
To investigate if JC virus (JCV) can be involved in the pathogenesis of Alzheimer's disease (AD) and astrocytomas.A nested polymerase chain reaction (PCR) was used for the detection of JCV DNA in autopsy brain material (cerebral white matter) and cerebrospinal fluid (CSF) specimens from patients with AD and age-matched control patients without ...
G, Bogdanovic   +6 more
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JC Virus

Nihon rinsho. Japanese journal of clinical medicine, 2003
Joseph Berger   +2 more
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Nested PCR for detection of BK virus and JC virus DNA

Clinical and Diagnostic Virology, 1994
A nested polymerase chain reaction (PCR) was developed to detect BK virus (BKV) and JC virus (JCV) DNA sequences. The unique clevage site for BamHI restriction enzyme was located in teh JCV amplimer and cleavage was used to differentiate between BKV and JCV.Twenty-three urine specimens from 17 bone marrow recipients with haemorrhagic cystitis and one ...
G, Bogdanovic   +7 more
openaire   +3 more sources

Transforming Activities of JC Virus Early Proteins

2007
Polyomaviruses, as their name indicates, are viruses capable of inducing a variety of tumors in vivo. Members of this family, including the human JC and BK viruses (JCV, BKV), and the better characterized mouse polyomavirus and simian virus 40 (SV40), are small DNA viruses that commandeer a cell's molecular machinery to reproduce themselves. Studies of
Richard J, Frisque   +2 more
openaire   +2 more sources

JC virus leukoencephalopathy complicating Wegener’s granulomatosis

Joint Bone Spine, 2003
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus. It occurs in association with immunodepression due, for instance, to a hematological malignancy, HIV infection, or immunosuppressive therapy for an organ transplant or systemic disease.
Christian, Pagnoux   +6 more
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Chromatin mimicry by human JC virus

Chronically persistent viruses are integral components of the organismal ecosystem in humans and animals 1 2 . Many of these viruses replicate and accumulate within the cell nucleus 3 .
Uwe Schaefer   +14 more
openaire   +2 more sources

Molecular prevalence of JC virus in Tehran, Iran.

Gastroenterology and hepatology from bed to bench, 2012
Since data about prevalence of JC virus in Iranian population is scarce, this study was designed to evaluate the prevalence of JC virus in healthy individuals who had attended Fajr hospital and Farjam clinical laboratory in Tehran, Iran.JC virus is the causative agent of progressive multifocal encephalopathy (PML) in individuals with suppressed immune ...
Majidizadeh Bozorgi, Sajjad   +10 more
openaire   +2 more sources

Structure and function of JC virus T' proteins

Journal of Neurovirology, 2001
The initial sequence analyses of the primate polyomavirus genomes conŽrmed the identity of 2 proteins, the large and small tumor antigens (TAg and tAg), encoded by the viral early regions. These multifunctional regulatory proteins are translated from transcripts generated by alternative splicing of the viral early mRNA. TAg, and to a lesser extent tAg,
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JC Virus infection of the brain

2012
Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information ...
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