Results 31 to 40 of about 2,027,813 (387)

Prevalence of antibodies to the BK and JC papovaviruses in isolated populations Prevalência de anticorpos contra os papovavirus BK e JC em populações isoladas

Revista de Saúde Pública, 1977
A total of 173 sera from isolated Brazilian Indian populations, 39 from the Diauarun area, and 68 from the Alto Xingú area, respectively in the North and the South of the Xingú National Park and 66 Kren-Akorore Indians, were examined for hemagglutination
J. A. N. Candeias, R. G. Baruzzi, S. Pripas, M. lunes   +3 more
doaj   +1 more source

Oligosaccharides as Receptors for JC Virus [PDF]

Journal of Virology, 2002
ABSTRACT JC virus (JCV) belongs to the polyomavirus family of double-stranded DNA viruses and in humans causes a demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy. Its hemagglutination activity and entry into host cells have been reported to depend on an N-linked glycoprotein containing sialic ...
Rika, Komagome, Hirofumi, Sawa, Takashi, Suzuki, Yasuo, Suzuki, Shinya, Tanaka, Walter J, Atwood, Kazuo, Nagashima   +6 more
openaire   +2 more sources

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy [PDF]

, 2006
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Barkhof, F., Clifford, D.B., Curfman, B., Fahle, G., Fischer, S., Habil, M., Hou, J., Jäger, H.R., Major, E.O., Miszkiel, K., Mueller-Lenke, N., Radue, E.-W., Ryschkewitsch, C., Sanchez, E., Yousry, T.A.   +14 more
core   +1 more source

Jc Virus-Induced Progressive Multifocal Leukoencephalopathy [PDF]

Future Virology, 2010
Progressive multifocal encephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS), caused by the lytic infection of oligodendrocytes by a human polyomavirus, JC virus (JCV). PML is rare disease but mostly develops in patients with underlying immunosuppressive conditions, including Hodgkin's lymphoma, lymphoproliferative ...
A Sami, Saribas, Ahmet, Ozdemir, Cathy, Lam, Mahmut, Safak   +3 more
openaire   +2 more sources

Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate [PDF]

, 2015
BACKGROUND: Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence.
Antje Bornemann, Felix Bischof, Nele Dammeier, Till-Karsten Hauser, Victoria Schubert   +4 more
core   +1 more source

JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]

, 2018
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena, Ciardi, Maria R., Cortese, Antonio, D’Abramo, Alessandra, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Lichtner, Miriam, Mastroianni, Claudio M., Morreale, Manuela, Oliva, Alessandra, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Rodio, Donatella Maria, Vullo, Vincenzo, Zingaropoli, Maria A.   +16 more
core   +3 more sources

Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]

, 2016
The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi, A Laroni, A Petrovic, Ada Francia, Alessandra D’Abramo, Alessandra Oliva, Anna Bellizzi, B Engelhardt, BL Padgett, C Bozic, C Tornatore, Claudia D’Agostino, Claudio Maria Mastroianni, D Jing, E Pucci, Elena Anzivino, EM Frohman, EM Johnson, Enrico Millefiorini, EO Major, EO Major, F Serana, F Taguchi, G Defer, H Bonig, K Khalili, L Börnsen, L Gorelik, LJ Marshall, M Niino, Manuela Morreale, Marco Iannetta, Maria Antonella Zingaropoli, Maria Rosa Ciardi, MC Monaco, ME Hemler, P Maenetje, RA Rudick, RM Ransohoff, Robert Shin Fujinami, RR Lobb, S Beltrami, SA Houff, SA Sadiq, Sara Lo Menzo, Simona Pontecorvo, T Van Loy, Valeria Pietropaolo, Vincenzo Vullo, WJ Atwood, Y Chen, Ö Yaldizli   +51 more
core   +17 more sources

Progressive multifocal leukoencephalopathy: new concepts

Arquivos de Neuro-Psiquiatria, 2013
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
doaj   +1 more source

Immunological biomarkers identifying natalizumab-treated multiple sclerosis patients at risk of progressive multifocal leukoencephalopathy [PDF]

, 2014
Natalizumab-induced progressive multifocal leukoencephalopathy (PML) appears to be unleashed by complex interactions between viral and immunological host factors leading the latent form of JC virus to become pathogenic.
A.SOTTINI, D.BERTOLI, F.SERANA, L.CAIMI, L.IMBERTI, M. VAGLIO TESSITORE, M.CHIARINI, R.CAPRA, V.GIUSTINI   +8 more
core   +1 more source

T' Proteins Influence JC Virus Biology [PDF]

Journal of Neurovirology, 2003
The JC virus early mRNA is alternatively spliced to yield five transcripts that encode large T antigen, small t antigen, T'(135), T'(136), and T'(165). The splicing process is regulated differentially in transformed versus lytically infected cells and temporally during the course of a productive infection. The authors have identified a potential exonic
Richard J, Frisque, Brigitte, Bollag, Shiva K, Tyagarajan, Lisa H, Kilpatrick   +3 more
openaire   +2 more sources