Results 11 to 20 of about 211 (93)

Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues [PDF]

BMC Cancer, 2008
Background Breast carcinomas represent a heterogeneous group of tumors diverse in behavior, outcome, and response to therapy. Identification of proteins resembling the tumor biology can improve the diagnosis, prediction, treatment selection, and ...
Buršíková Eva, Matoušková Eva, Šanda Miloslav, Smutná Kateřina, Selicharová Irena, Vydra Jan, Prchalová Markéta, Velenská Zuzana, Coufal David, Jiráček Jiří   +9 more
doaj   +7 more sources

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2 [PDF]

Frontiers in Endocrinology, 2019
Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein ...
Petr Pompach, Cristina M. Viola, Jelena Radosavljević, Jingjing Lin, Jiří Jiráček, Andrzej M. Brzozowski, Irena Selicharová   +6 more
doaj   +2 more sources

Structural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes of the young. [PDF]

PLoS ONE, 2014
The insulin gene mutation c.137G>A (R46Q), which changes an arginine at the B22 position of the mature hormone to glutamine, causes the monogenic diabetes variant maturity-onset diabetes of the young (MODY).
Květoslava Křížková, Václav Veverka, Lenka Maletínská, Rozálie Hexnerová, Andrzej M Brzozowski, Jiří Jiráček, Lenka Žáková   +6 more
doaj   +2 more sources

Late-stage labeling of diverse peptides and proteins with iodine-125 [PDF]

Journal of Pharmaceutical Analysis
The preparation of specifically iodine-125 (125I)-labeled peptides of high purity and specific activity represents a key tool for the detailed characterization of their binding properties in interaction with their binding partners.
Aleš Marek, Břetislav Brož, Michal Kriegelstein, Gabriela Nováková, Jana Hojcsková, Miroslava Blechová, Lenka Žáková, Jiří Jiráček, Lenka Maletínská   +8 more
doaj   +2 more sources

A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations [PDF]

Molecules, 2015
We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc ...
Benjamin Fabre, Jan Pícha, Václav Vaněk, Miloš Buděšínský, Jiří Jiráček   +4 more
doaj   +2 more sources

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression [PDF]

Molecular Metabolism
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis   +13 more
doaj   +2 more sources

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. [PDF]

J Biol Chem, 2016
Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Hexnerová R, Křížková K, Fábry M, Sieglová I, Kedrová K, Collinsová M, Ullrichová P, Srb P, Williams C, Crump MP, Tošner Z, Jiráček J, Veverka V, Žáková L.   +13 more
europepmc   +4 more sources

Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. [PDF]

J Biol Chem, 2017
Human insulin is a pivotal protein hormone controlling metabolism, growth and ageing, and whose malfunctioning underlies diabetes, some cancers and neuro-degeneration.
Palivec V, Viola CM, Kozak M, Ganderton TR, Křížková K, Turkenburg JP, Haluŝková P, Žáková L, Jiráĉek J, Jungwirth P, Brzozowski AM.   +10 more
europepmc   +3 more sources

Studium zásobních forem insulinu v sekrečních granulích β buněk pankreatu [PDF]

, 2023
V této disertační práci jsme se zaměřili na komplexní výzkum zaměřený na produkci, skladování a sekreci inzulínu -buňkami pankreatu. Úspěšně jsme vyvinuli nový test pro rychlé a citlivé stanovení koncentrace inzulínu v biologických vzorcích.
Asai, Seiya
core  

Insulin-like Growth Factor 1 Analogs Clicked in the C Domain : Chemical Synthesis and Biological Activities [PDF]

, 2017
Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials toward the ...
Andrzej M. Brzozowski, Bayne M. L., Du Y. C., Irena Selicharová, Jan Pícha, Jiří Jiráček, Kateřina Macháčková, Lenka Žáková, Martina Chrudinová, Michaela Collinsová, Miloš Buděšínský, Václav Vaněk   +11 more
core   +2 more sources