Mimetics of polypeptide hormones from the insulin family [PDF]
, 2021 1 The family of human insulin-like peptide hormones includes insulin, insulin-like growth factors 1 and 2 (IGF-1 and 2), relaxins 1-3, and INSL3-6 polypeptides.
Mařík, Vojtěch
core
Strategies and results in the development of insulin derivatives for the treatment of diabetes [PDF]
, 2023 The aim of this bachelor's thesis is to present insulin analogs and to analyse the direction of development of these organic compounds. The text contains basic information on this subject (e.g.
Pokorný, Štěpán
core +1 more source
Structural basis of Drosophila insulin receptor activation by DILP2 hormoneStructural basis of Drosophila insulin receptor activation by DILP2 hormone [PDF]
Open BiologyInsulin-related hormones regulate key life processes in the animal kingdom, from metabolism to growth, lifespan and ageing, through an evolutionarily conserved insulin and insulin-like hormones signalling axis (IIS). In humans, the IIS axis is controlled
Talha Shafi +8 more
doaj +1 more source
Development of instrumentation and high-throughput screening methods for peptide ligand discovery and validation [PDF]
, 2021 Peptides are used as synthetically available and easily derivatizable scaffold upon which it is possible to develop ligands targeting broad spectrum of biological targets.
Kryštůfek, Robin
core
Journal of Biological Chemistry, 2012 Background: Insulin-like growth factor (IGF) II interacts with IR-A and is a more powerful mitogen than insulin. Results: IGF-II and insulin differ in regulating insulin receptor (IR)-A trafficking and stability. Conclusion: Compared with insulin, IGF-II
A. Morcavallo +8 more
semanticscholar +1 more source
The Specific Features of Collectivization in Svitavy District between 1949 and 1960 [PDF]
, 2015 The thesis deals with the process of collectivization in the area which was the called Svitavy National District Committee. The thesis represents economic and social transformation after the expulsion of Germans from Czechoslovakia.
Jiráček, Jiří
core
New insulin-like growth factor 1 (IGF-1) analogs for receptor studies and therapeutic applications [PDF]
, 2023 The insulin/IGF system is an evolutionary conserved network that includes three closely related peptide hormones (insulin, IGF-1 and IGF-2), three homologous tyrosine kinase receptors (IR-A, IR-B and IGF-1R), a distinct IGF-2 receptor (IGF-2R), and six ...
Lin, Jingjing
core +1 more source
Preparation of insulin analogs for the study of interactions with insulin receptors. [PDF]
, 2018 Insulin jako jeden z důležitých hormonů lidského organismu se podílí na řadě metabolických procesů. Jednou z funkcí insulinu je pak regulace hladiny glukosy v krvi a jejího vstupu do tkání, ale i stimulace růstu buněk.
Hanková, Kateřina
core
Synthesis and characterization of new insulin analogs with a triazole bridge at the C-terminus of the B chain [PDF]
, 2018 Insulin is a peptide hormone responsible for maintaining glucose homeostasis in the circulation. Insulin interacts with two isoforms of the insulin receptor, IR-A and IR-B, which have different tissue distribution.
Kuntová, Vendula
core
Journal of Biological Chemistry, 1995 Several hundred phosphinic peptides having the general formula Z-(L,D)Pheψ(PO2CH2)(L,D)Xaa‘-Yaa‘-Zaa‘, where Xaa‘ = Gly or Ala and Yaa‘ and Zaa‘ represent 20 different amino acids, have been synthesized by the combinatorial chemistry approach.
J. Jiráček +6 more
semanticscholar +1 more source