Structural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes of the young. [PDF]
PLoS ONE, 2014 The insulin gene mutation c.137G>A (R46Q), which changes an arginine at the B22 position of the mature hormone to glutamine, causes the monogenic diabetes variant maturity-onset diabetes of the young (MODY).
Květoslava Křížková +6 more
doaj +2 more sources
A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations [PDF]
Molecules, 2015 We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc ...
Benjamin Fabre +4 more
doaj +2 more sources
Rational steering of insulin binding specificity by intra-chain chemical crosslinking. [PDF]
Sci Rep, 2016 Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentially bind to the
Viková J +16 more
europepmc +2 more sources
Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using
BMC Cancer, 2008 Background Breast carcinomas represent a heterogeneous group of tumors diverse in behavior, outcome, and response to therapy. Identification of proteins resembling the tumor biology can improve the diagnosis, prediction, treatment selection, and ...
Buršíková Eva +9 more
doaj +2 more sources
A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding. [PDF]
J Biol Chem, 2018 Insulin and insulin-like growth factor 1 (IGF-1) are closely related hormones involved in the regulation of metabolism and growth. They elicit their functions through activation of tyrosine kinase–type receptors: insulin receptors (IR-A and IR-B) and IGF-
Chrudinová M +9 more
europepmc +2 more sources
Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. [PDF]
J Biol Chem, 2017 Human insulin is a pivotal protein hormone controlling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neurodegeneration.
Palivec V +10 more
europepmc +2 more sources
Structural integrity of the B24 site in human insulin is important for hormone functionality. [PDF]
J Biol Chem, 2013 Background: The structure of the C-terminal B21-B30 chain of insulin bound to the insulin receptor remains undetermined. Results: The structures of B24-modified insulins were determined.
Žáková L +7 more
europepmc +2 more sources
Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues. [PDF]
Proc Natl Acad Sci U S A, 2010 Jirácek J +6 more
europepmc +2 more sources
Jiří Kolář's Nový don Quijote [PDF]
, 2008 My thesis "Jiří Kolář's Nový don Quijote" focuses on the hitherto unknown manuscript of Jiří Kolář called Nový don Quijote (The New Don Quixote). It was written between 1936 and 1938/1939; in Kolář's bibliography it thus occupies a position between the ...
Říha, Jakub
core +1 more source