Results 11 to 20 of about 128,017 (118)

Characterization of viral insulins reveals white adipose tissue-specific effects in mice [PDF]

Molecular Metabolism, 2021
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to human ...
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis   +10 more
doaj   +3 more sources

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels [PDF]

Open Biology, 2020
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not ...
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková   +12 more
doaj   +3 more sources

Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities. [PDF]

Int J Pept Res Ther, 2023
Insulin-like growth factor 1 (IGF-1) and its IGF-1 receptor (IGF-1R) belong to an important biological system that is involved in the regulation of normal growth, but that has also been recognized as playing a role in cancer.
Lin J, Asai S, Selicharová I, Mitrová K, Kaminský J, Young E, Jiráček J.   +6 more
europepmc   +2 more sources

The final walk with preptin. [PDF]

PLoS One
Preptin, a 34-amino acid peptide derived from pro-IGF2, is believed to influence various physiological processes, including insulin secretion and the regulation of bone metabolism.
Mrázková L, Lubos M, Voldřich J, Kužmová E, Zrubecká D, Gwozdiaková P, Buděšínský M, Asai S, Marek A, Pícha J, Tencerová M, Ferenčáková M, Barrera GA, Kaminský J, Jiráček J, Žáková L.   +15 more
europepmc   +2 more sources

Multiscale Computational Protocols for Accurate Residue Interactions at the Flexible Insulin-Receptor Interface. [PDF]

J Chem Inf Model
The quantitative characterization of residue contributions to protein–protein binding across extensive flexible interfaces poses a significant challenge for biophysical computations.
Yurenko YP, Muždalo A, Černeková M, Pecina A, Řezáč J, Fanfrlík J, Žáková L, Jiráček J, Lepšík M.   +8 more
europepmc   +2 more sources

Viral insulin/IGF-like peptides inhibit IGF-1 receptor signaling to enhance viral replication. [PDF]

Cell Rep
SUMMARY The insulin/insulin growth factor (IGF) system plays a central role in regulating metabolism and growth. We identified viral insulin/IGF1-like peptides (VILPs) in Iridoviridae and investigated their role in host-virus interactions.
Chuard A, Nesarajah K, Danazumi K, Reiners K, Zhang F, Levintov L, Lubos M, Žáková L, Ruggera R, McMenamin S, Vashisth H, Jiráček J, Dimarchi R, Altindis E.   +13 more
europepmc   +2 more sources

Design of Potent Mannose-6-Phosphate Derivatives as Ligands for CI-M6P/IGF2R Using Fluorescence Polarization Assay. [PDF]

Chemistry
The cation‐independent mannose‐6‐phosphate/IGF2 receptor (CI‐M6P/IGF2R) plays a crucial role in transporting lysosomal enzymes and other ligands. In this study, we designed and synthesized novel stable mannose‐6‐phosphate (M6P) derivatives to enhance ...
Mrázková L, Hladoníková K, Toncarová B, Fischer M, Zýka J, Kozák J, Kráľ M, Kožíšek M, Jiráček J, Kaminský J, Parkan K, Žáková L.   +11 more
europepmc   +2 more sources

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2 [PDF]

Frontiers in Endocrinology, 2019
Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein ...
Petr Pompach, Cristina M. Viola, Jelena Radosavljević, Jingjing Lin, Jiří Jiráček, Andrzej M. Brzozowski, Irena Selicharová   +6 more
doaj   +2 more sources

Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

ChemMedChem, Volume 19, Issue 11, June 3, 2024.
Large combinatorial libraries of bipodal constructs with two distinct peptides were synthesized on resin beads and assessed for insulin receptor binding via antibodies and flow cytometry. The outcomes were characterized by robust non‐specific interactions.
Irena Selicharová, Benjamin Fabre, María Soledad Garre Hernández, Marta Lubos, Jan Pícha, Zdeněk Voburka, Katarína Mitrová, Jiří Jiráček   +7 more
wiley   +2 more sources

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. [PDF]

J Biol Chem, 2019
Information on how insulin and insulin-like growth factors 1 and 2 (IGF-1 and -2) activate insulin receptors (IR-A and -B) and the IGF-1 receptor (IGF-1R) is crucial for understanding the difference in the biological activities of these peptide hormones.
Macháčková K, Mlčochová K, Potalitsyn P, Hanková K, Socha O, Buděšínský M, Muždalo A, Lepšík M, Černeková M, Radosavljević J, Fábry M, Mitrová K, Chrudinová M, Lin J, Yurenko Y, Hobza P, Selicharová I, Žáková L, Jiráček J.   +18 more
europepmc   +2 more sources