Results 141 to 150 of about 297,973 (327)
Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death
Cell Reports, 2018 Summary: The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals.
Haruko Miura +3 more
doaj +1 more source
Role of JNK signaling in oral cancer: A mini review
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017 JNKs (c-Jun N-terminal kinases) belong to mitogen-activated protein kinases’ family and become activated by several growth factors, stress, radiation, and other extracellular signals.
I. Gkouveris, N. Nikitakis
semanticscholar +1 more source
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source
BMC Cell Biology, 2006 Background The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells. The mechanism of mammalian JNK
Iordanov Mihail S +2 more
doaj +1 more source
EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets
Advanced Science, EarlyView.Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang +4 more
wiley +1 more source
Generalized weights and bounds for error probability over erasure channels [PDF]
, 2014 New upper and lower bounds for the error probability over an erasure channel are provided, making use of Wei's generalized weights, hierarchy and spectra.
Firer, Marcelo, Lemes, Leandro Cruvinel
core
MAPK/JNK signalling: a potential autophagy regulation pathway
Bioscience Reports, 2015 Herein, MAPK/JNK signalling is proposed as a potential autophagy regulation pathway for the transcription-dependent or independent role.
Yuan Zhou +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
Neural Plasticity, 2017 The c-Jun N-terminal kinase (JNK) is part of a stress signalling pathway strongly activated by NMDA-stimulation and involved in synaptic plasticity. Many studies have been focused on the post-synaptic mechanism of JNK action, and less is known about JNK ...
Silvia Biggi +8 more
doaj +1 more source