Results 151 to 160 of about 164,331 (306)
Journal of Biological Research - ThessalonikiEndometrial cancer encompasses a diverse range of tumors originating from the uterine lining, with distinct histological and genetic characteristics. Genetically, key alterations in genes like PTEN, PIK3CA, KRAS, and microsatellite instability contribute
Paraskevi Kyrizaki +2 more
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
Jackknife bias‐corrected variance estimation for the generalized regression estimator
Canadian Journal of Statistics, EarlyView.Abstract Commonly used variance estimators for the generalized regression estimator (GREG) are based on Taylor linearization and jackknife. Traditionally, a jackknife GREG variance estimator is obtained by jackknifing GREG, which consists of computing GREG from each of several subsamples of the parent sample, and estimating the variance of the parent ...
Marius Stefan, J.N.K Rao
wiley +1 more source
Deregulated JNK signaling enhances apoptosis during hyperthermia
c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli. However, the molecular mechanism underlying heat-induced JNK activation is largely unknown.
Shinichi Sato (327937) +7 more
core +2 more sources
Stimulation-specific contribution of p38 and JNK to IFN-beta gene expression in human macrophages
, 2007 Induction of interferon-beta (IFN-beta) gene expression is a tightly regulated process, and a plethora of studies identified the signal transduction pathway TANK-binding kinase-1 (TBK-1)/IFN regulatory factor-3 (IRF-3) as essential to the induction of ...
Schweizer, Matthias +2 more
core +1 more source
Cancer Nexus, EarlyView.ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang +4 more
wiley +1 more source
JNK regulates FoxO-dependent autophagy in neurons
, 2016 The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles.
Reilly, Judith +3 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu +4 more
wiley +1 more source