Results 141 to 150 of about 177,354 (301)
BMEMat, EarlyView.This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao +3 more
wiley +1 more source
The role of JNK in the development of hepatocellular carcinoma
, 2011 The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that accounts for JNK-regulated tumor growth is unclear.
David S. Garlick +3 more
core +1 more source
BMEMat, EarlyView.This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang +7 more
wiley +1 more source
Drosophila male genitalia rotation depends on permissive remodeling of the posterior abdomen
Developmental Dynamics, EarlyView.Abstract Background One of the most characteristic morphogenetic processes in Drosophila is the 360° rotation of the male pupal genital disc. This movement is driven by the myosin Myo1D, whose expression in the genital disc is controlled by the Hox gene Abdominal‐B (Abd‐B).
Nuria Prieto +6 more
wiley +1 more source
Effects of Metformin on JNK Signaling Pathway and PD-L1 Expression in Triple Negative Breast Cancer [PDF]
Ruibin Wang,1,* Yanjie Zhao2,* 1Department of Emergency, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing ...
Wang R, Zhao Y
core
PPARγ agonists induce JNK activation on primary hippocampal neurons.
, 2013 (A) Hippocampal neurons were treated with TGZ (10 µM) and RGZ (10 µM), in the presence or absence of SP (100 nM) for 72 h. After treatment neurons were fixed and double immunolabeled with anti-p-JNK (green) and anti-tau-1 (red) antibodies, respectively ...
Deny Cabezas (417322) +6 more
core +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
CGZ increases p-JNK levels on primary hippocampal neurons.
, 2013 Cultured hippocampal neurons (15 DIV) were treated with CGZ and GW for 72 h, and cells extracts were prepared for p-JNK and total JNK protein levels detection by western blot.
Deny Cabezas (417322) +6 more
core +1 more source
Food Safety and Health, EarlyView.Punicic acid (PA) was enriched and purified from PSO by molecular distillation with significant anti‐inflammatory activity to RAW264.7 cells, as well as to zebrafish. Anti‐inflammatory mechanism involved regulating NF‐κB and MAPK signaling pathways. ABSTRACT Punicic acid (PA) is the main fatty acid in pomegranate seeds, which shows multiple biological ...
Mengqi Zhang +8 more
wiley +1 more source