Results 131 to 140 of about 177,354 (301)

JNK signaling dominance in hyperthermia

Cell Stress and Chaperones
Hyperthermia is a promising anticancer treatment that induces heat stress, stimulating various signal transduction pathways to maintain cellular homeostasis. Mitogen-activated protein kinases (MAPKs) link various extracellular stimuli with cytoplasmic and nuclear mediators through a three-tiered cascade of kinases, including MAPKs, MAP2Ks, and MAP3Ks ...
Enomoto, Atsushi, Fukasawa, Takemichi
openaire   +2 more sources

Acupuncture inhibits JNK activation after SCI.

, 2013
At POD 31, 1 h after AP treatment, lumbar (L4-L5) spinal tissues were isolated and total lysates or frozen tissue sections were prepared as described in the Methods section (n = 4). (a) Western blots of p-JNK.
Jee Y. Lee (455790), Doo C. Choi (455791), Tae Y. Yune (455793), Tae H. Oh (455792)   +3 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

A stiff ECM activates the ERK and JNK signaling pathway.

, 2015
(A) hMSCs were plated on a 1.37 or 4.47 kPa hydrogel, and after 12 h, cell lysates were prepared and analyzed by immunoblotting. To assess the activity of ERK and JNK, phosphorylated ERK (p-ERK) and phosphorylated JNK (p-JNK) antibodies were used ...
Mi Gyeong Jeong (782116), Mi Ran Byun (782114), A. Rum Kim (540744), Hang Jun Cho (540745), Jun-Ha Hwang (540743), Kyung Min Kim (540742), Jeong-Ho Hong (540747), Eun Sook Hwang (181978), Yo Han Lee (782115), Juwon Kim (478195)   +9 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Characterization of missense mutations in the tumor suppressor gene Cyld that are associated with endometrial cancer

Journal of Biological Research - Thessaloniki
Endometrial cancer encompasses a diverse range of tumors originating from the uterine lining, with distinct histological and genetic characteristics. Genetically, key alterations in genes like PTEN, PIK3CA, KRAS, and microsatellite instability contribute
Paraskevi Kyrizaki, Alkis Apostolos Katsetsiadis, George Mosialos   +2 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Deregulated JNK signaling enhances apoptosis during hyperthermia

c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli. However, the molecular mechanism underlying heat-induced JNK activation is largely unknown.
Shinichi Sato (327937), Hiroshi Terunuma (11966163), Noriko Hosoya (12471050), Ayumi Yoshizaki (811275), Atsushi Enomoto (323918), Keiichi Nakagawa (818625), Kiyoshi Miyagawa (14567), Takemichi Fukasawa (10006511)   +7 more
core   +2 more sources

A cytoplasmic inhibitor of the JNK signal transduction pathway

, 2008
The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cytoplasmic protein that binds specifically to JNK [the JNK interacting
Cavanagh, Julie, Sawyers, Charles L., Raitano, Art, Dickens, Martin, Davis, Roger J., Xia, Zhengui, Rogers, Jeffrey Scott, Halpern, Jocelyn R., Greenberg, Michael E.   +8 more
core   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source