Results 171 to 180 of about 177,354 (301)

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

UBE2S promotes gastric cancer progression through RACGAP1 stabilization associated with K292-dependent K63-linked ubiquitination. [PDF]

Cancer Biol Ther
Cheng H, Zhou Z, Cheng Q, Sui Z.
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

The JNK signaling pathway as a potential new target for depression

, 2018
c-Jun氨基端激酶（c-Jun N-terminal kinase,JNK）属于丝裂原激活的蛋白激酶（mitogen-activated protein kinase,MAPK）家族中受应激激活的一类激酶.众多研究表明,在神经萎缩、炎症反应、氧化应激、心理应激事件中均显著涉及JNK的激活,而这些事件均与抑郁症紧密相联.近年来运用基因敲除和JNK抑制剂等手段证明JNK的确参与抑郁症状的调控;同时不少抗抑郁药的疗效涉及对JNK活性的调节,这些已初步确立JNK与抑郁症之间的关联 ...
林文娟, 张军涛
core  

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Combination of Chenpi and Banxia alleviates synovial inflammation in a rat model of rheumatoid arthritis by targeting the JNK/AP-1 signaling pathway. [PDF]

Front Immunol
Zhang W, Li Y, Zhang X, Zhang J, Du Y, Han X, Cui R, Li Y, Meng F, Meng D.   +9 more
europepmc   +1 more source

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥ 20 weeks to a tertiary fetal medicine unit (2020–2025).
Hadas Miremberg, May Shabat, Maya Stok, Vered Offer Glasner, Adi Botvinik, Mordechai Shohat, Michal Levy, Yuval Yaron, Roee Birnbaum, Sharon Perlman, Gustavo Malinger, Karina Krajden Haratz   +11 more
wiley   +1 more source

Claudin 1 promotes blood-borne metastasis by modulating the Src/Ezrin signaling pathway in high-CLDN1 triple-negative breast cancer model. [PDF]

Mol Cell Oncol
Yang H, Lu H, Wang W, Ma J, Xiong L, Zou Y, Fu J.   +6 more
europepmc   +1 more source

Pesticide use in integrated pest and pollinator management framework to protect pollinator health

Pest Management Science, Volume 81, Issue 4, Page 1691-1696, April 2025.
Integrated pest management (IPM) emphasizes non‐chemical methods, with pesticides as a last resort, while integrated pest and pollinator management (IPPM) integrates pollinator health into pest control strategies. Abstract Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering ...
Ngoc T Phan, David J Biddinger, Edwin G Rajotte, Guy Smagghe, Gadi VP Reddy, Zong‐Xin Ren, Neelendra K Joshi   +6 more
wiley   +1 more source