Caffeic Acid Protects Keratinocytes from PM<sub>2.5</sub> by Regulating ROS, Mitochondrial Integrity, and JNK Activation. [PDF]
Biomol Ther (Seoul)Senavirathna HMMM +5 more
europepmc +1 more source
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, EarlyView.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
The RIPK3 Inhibitor GSK872 Attenuates Inflammation and Necroptosis via Modulation of the JNK Signaling Pathway in LPS-Stimulated Microglia. [PDF]
Biomol Ther (Seoul)Park JS +4 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
ADAM15 promotes the progression and metastasis of hepatocellular carcinoma by activating the JNK/p38 pathway. [PDF]
Sci RepJunhui X, Mengyun S.
europepmc +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel +3 more
wiley +1 more source
Fusobacterium nucleatum-Derived Outer Membrane Vesicles Disrupt Epithelial Barrier in Oral Lichen Planus via JNK/c-JUN Mediated Claudin-4 Downregulation. [PDF]
Int Dent JShao R, Wang Z, Yang C, Chen J, Du G.
europepmc +1 more source
Pediatric Discovery, EarlyView.Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu +4 more
wiley +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Wrist-Ankle Acupuncture Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Neuronal α7 Nicotinic Acetylcholine Receptor-Dependent Modulation of Spinal Glutamatergic/NMDAR Signaling. [PDF]
J Pain ResLan Y +5 more
europepmc +1 more source