Results 211 to 220 of about 164,331 (306)

The RIPK3 Inhibitor GSK872 Attenuates Inflammation and Necroptosis via Modulation of the JNK Signaling Pathway in LPS-Stimulated Microglia. [PDF]

Biomol Ther (Seoul)
Park JS, Kim DY, Kim SE, Hyun JW, Kim HS.   +4 more
europepmc   +1 more source

Pesticide use in integrated pest and pollinator management framework to protect pollinator health

Pest Management Science, Volume 81, Issue 4, Page 1691-1696, April 2025.
Integrated pest management (IPM) emphasizes non‐chemical methods, with pesticides as a last resort, while integrated pest and pollinator management (IPPM) integrates pollinator health into pest control strategies. Abstract Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering ...
Ngoc T Phan, David J Biddinger, Edwin G Rajotte, Guy Smagghe, Gadi VP Reddy, Zong‐Xin Ren, Neelendra K Joshi   +6 more
wiley   +1 more source

Caffeic Acid Protects Keratinocytes from PM_2.5 by Regulating ROS, Mitochondrial Integrity, and JNK Activation. [PDF]

Biomol Ther (Seoul)
Senavirathna HMMM, Piao MJ, Kang KA, Madhuwantha MPL, Park J, Hyun JW.   +5 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

ADAM15 promotes the progression and metastasis of hepatocellular carcinoma by activating the JNK/p38 pathway. [PDF]

Sci Rep
Junhui X, Mengyun S.
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Anti‐Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy

Phytotherapy Research, EarlyView.
Chamaecrista nomame (CN) and its active compound luteolin attenuate allergic airway inflammation by inhibiting mast cell activation and suppressing NF‐κB/MAPK signaling, leading to reduced cytokine production and OVA‐specific IgE levels. ABSTRACT Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation ...
Tae Kyeom Kang, Myungsuk Kim, Tam Thi Le, Geon Park, Yuna Jung, Hyobin Jeong, Youngsang Yoo, Wook‐Bin Lee, Sang Hoon Jung   +8 more
wiley   +1 more source

Fusobacterium nucleatum-Derived Outer Membrane Vesicles Disrupt Epithelial Barrier in Oral Lichen Planus via JNK/c-JUN Mediated Claudin-4 Downregulation. [PDF]

Int Dent J
Shao R, Wang Z, Yang C, Chen J, Du G.
europepmc   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Cadmium-induced apoptosis via ROS/JNK pathway in chicken primary kidney cells and antagonism of taxifolin. [PDF]

Poult Sci
Zhang Y, Li Z, Liu X, Zhao B, Xu T.
europepmc   +1 more source