Results 201 to 210 of about 177,354 (301)

Cilostazol ameliorates high glucose-induced osteoblast dysfunction by modulating mitogen-activated protein kinase signaling and the OPG/RANKL axis. [PDF]

Exp Ther Med
Kim JE, Park H.
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Norcantharidin induces apoptosis in hepatocellular carcinoma MHCC97-H cells in association with altered NF-κB/IκBα signaling dynamics and JNK activation. [PDF]

Am J Transl Res
Wang D, Guo J, Zhang X, Yin F, Cui D.
europepmc   +1 more source

Essential Oils From the Fruit of Amomum villosum Lour. Alleviate LPS‐Induced Neuroinflammation by Repressing PI3K‐Akt and MAPK Signaling Pathways

Phytotherapy Research, EarlyView.
Amomum villosum essential oil (AVEO) alleviates LPS‐induced neuroinflammation and cognitive and behavioral dysfunction by suppressing PI3K‐Akt and MAPK signaling pathways, modulating inflammatory responses, and restoring metabolic homeostasis, thereby exerting neuroprotective effects. ABSTRACT Amomum villosum Lour.
Hongjin Wang, Xuetong Li, Zhenhai Huang, Shanshan Luo, Jiyu Weng, Shuanghe Wang, Guofeng Shi, Yixi Zeng, Weishan Wen, Lanyue Zhang, Junxia Zheng, Hui Li   +11 more
wiley   +1 more source

Statement of Retraction: Secreted frizzled-related protein 5 promotes angiogenesis of human umbilical vein endothelial cells and alleviates myocardial injury in diabetic mice with myocardial infarction by inhibiting Wnt5a/JNK signaling. [PDF]

Bioengineered
europepmc   +1 more source

Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain. [PDF]

Proc Natl Acad Sci U S A
Madasu C, Sirupangi T, Herrera GJ, Bohren KM, Sharma KL, Tan Z, Ta HM, Yuan F, Palaniappan M, Clementi C, Tang S, Unser AC, Wilkinson J, Robers MB, Guan X, Li F, Kim C, Sankaran B, Kommagani R, Chamakuri S, Young DW, Biem PY, Matzuk MM, Palmer SS, Monsivais D.   +24 more
europepmc   +1 more source

Butein Attenuates Cardiac Hypertrophy by Restoring Redox–Mitochondrial Homeostasis Through Nrf2–Sirt3 Signaling

Phytotherapy Research, EarlyView.
Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley   +1 more source

Targeting the IRE1α/XBP1 pathway in type 2 diabetes mellitus: from ER stress signaling to therapeutic opportunity. [PDF]

Mol Biol Rep
Obafemi OT, Ayeleso AO, Ekundayo BE, Obafemi BA, Adewale OB, Lebelo SL, Ntwasa M.   +6 more
europepmc   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Alantolactone Activates the Extracellular Signal-Regulated Kinase Signaling Pathway to Promote Tumor Necrosis Factor Receptor 1 Ectodomain Shedding. [PDF]

Molecules
Yarangsee P, Vu QV, Miyake Y, Kataoka T.
europepmc   +1 more source