Results 251 to 260 of about 262,074 (332)

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

TNIK as a molecular switch regulating platelet function in hemostasis and hyperlipidemia-associated thrombosis. [PDF]

Blood Adv
Li L, Chen X, Li J, Deng X, Sheng Y, Lu L, Hu H.   +6 more
europepmc   +1 more source

Spatiotemporal Co‐Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi‐Modal In Vivo Study

Small, EarlyView.
A spatiotemporal co‐delivery microneedle system (MN‐Mg) is developed for spinal cord injury repair. By generating hydrogen gas and magnesium ions in situ, this dual‐engine platform effectively scavenges ROS and modulates microglial polarization via the MAPK/AP‐1 signaling axis.
Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo, Yiwei Zhu, Yu Feng, Kun Xi, Liang Chen   +13 more
wiley   +1 more source

CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila. [PDF]

Cell Death Discov
Wang S, Qi B, Ma P, Zhang Y, Yin Y, Chen S, Deng H.   +6 more
europepmc   +1 more source

Andrographolide Reduces Cytokine Release and Cyclooxygenase-2 Expression by Inhibiting the JNK and NF-κB Pathways in Glioblastoma Cells Exposed to Cadmium

Thitima Kasemsuk, Pornpun Vivithanaporn, Pichsinee Woonfak, Phisit Khemawoot   +3 more
openalex   +2 more sources

NOB1 silencing inhibits the growth and metastasis of laryngeal cancer cells through the regulation of JNK signaling pathway

, 2016
Xin Gao, Jin Wang, Weiliang Bai, Wenyue Ji, Liping Wang   +4 more
openalex   +2 more sources

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

A new Jun amino-terminal kinase inhibitor, KRev-202, inhibits rat ischemic acute injury and the progression to renal fibrosis. [PDF]

Front Pharmacol
Nikolic-Paterson DJ, Tesch GH, Ozols E, Jarnagin K, Satoh Y, Webb DR, Squiers E, Grynberg K, Ma FY.   +8 more
europepmc   +1 more source

ALOE VERA STIMULATES CELL PROLIFERATION, CELL MIGRATION, EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A (VEGF-A), AND C-JUN N-TERMINAL KINASE-1 (JNK-1) ON FIBROBLAST CELL CULTURED OF DIABETIC RAT SKIN

, 2019
Insanul Firdaus, Nur Arfian, Mae Sri Hartati Wahyuningsih, Denny Agustiningsih   +3 more
openalex   +1 more source

Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH₂-terminal kinase (JNK) interacting protein exclusively expressed in testis

, 2005
Nirmala Jagadish, Ritu Rana, Deepshikha Mishra, Manoj Kumar, Anil Suri   +4 more
openalex   +2 more sources