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<i>Schisandra chinensis</i> Pomace Attenuates Scopolamine-Induced Cholinergic Dysfunction Associated with Changes in BDNF and JNK Signaling. [PDF]
Yoon JH +10 more
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The JNK signal transduction pathway
Current Opinion in Genetics and Development, 2002The c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding of the physiological function of the JNK pathway. Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival ...
Roger J Davis
exaly +4 more sources
JNK: A Key Modulator of Intracellular Signaling
Biochemistry (Moscow), 2004JNK is a family of stress activated protein kinase enzymes that is under intense study. JNK family members are involved in diverse phenomena, but the focus of research has been until now involvement of JNK in apoptosis. A great number of JNK substrates indeed play major roles in cell death.
Spiros Vlahopoulos
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JNK: a killer on a transcriptional leash
Cell Death & Differentiation, 2003Whether to live or die is arguably the most important decision a cell has to make, and the NF-B/Rel group of transcription factors is a key element in this decision. Since the discovery of the Anti-Apoptotic Function of NF-B in 1996, the number of publications dealing with the control of apoptosis by NF-B has increased at an astonishing pace – over 600
FRANZOSO G +2 more
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Science Signaling, 2009
The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain.
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The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain.
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The Role of JNK Proteins in Metabolism
Science Translational Medicine, 2010To combat metabolic diseases, therapeutic c-Jun N-terminal kinase (JNK) inhibitors must target multiple cell types.
Sara N, Vallerie +1 more
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The JNK Pathway and Neuronal Migration
Journal of Genetics and Genomics, 2007The c-Jun N-terminal kinases (JNKs) are important regulators of a variety of physiological and pathological processes both in the central and in the peripheral nervous systems. JNKs are considered as crucial mediators of neuronal cell death in response to stress and injury. However, recent studies have provided substantial evidence that the JNK pathway
Yiming, Sun, Tao, Yang, Zhiheng, Xu
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The Impact of JNK on Neuronal Migration
2013Incorrect placement of nerve cells during brain development leaves us at risk of diseases and conditions ranging from epilepsy and mental retardation to schizophrenia and dyslexia. The developing brain produces cells at an impressive rate, with up to 250,000 new cells generated every minute.
Coffey Eleanor Therese +1 more
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