Results 241 to 250 of about 177,354 (301)

Integrative transcriptomic analysis reveals KLHL2 downregulation as a potential driver of microglial inflammation in Alzheimer's disease via the WNK3/JNK/c-Jun axis. [PDF]

Neurotherapeutics
Yang Y, Dai C, Xu Z, Zhuo L, Xiang K, Lin X, Sun J, Liu J, Tong Q.   +8 more
europepmc   +1 more source

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

CircRNAs and Erectile Dysfunction: A Hybrid Review of Possible Interactions. [PDF]

Curr Issues Mol Biol
Triantis D, Dastamani C, Barboutis P, Petranis T, Michalakis C, Mavrakis D.   +5 more
europepmc   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways. [PDF]

Metab Brain Dis
Sravya K, Rao A, Harshitha P, Parithathvi A, Dsouza HS.   +4 more
europepmc   +1 more source

2-Hydroxyethyl Methacrylate Increases MMP-1 and MMP-3 Production in Human Gingival Fibroblasts. [PDF]

J Biochem Mol Toxicol
Okamoto R, Hosokawa Y, Hosokawa I, Fukui A, Miyake N, Ozaki K, Hosaka K.   +6 more
europepmc   +1 more source

Effective-Component Compatibility of Bufei Yishen Formula III Improves Chronic Obstructive Pulmonary Disease by Inhibiting Inflammatory Responses Through Blocking PTX3 Activation. [PDF]

J Inflamm Res
Lu R, Miao Y, Guan Q, Song M, Dong H, Tian Y, Ren Z, Zhang L.   +7 more
europepmc   +1 more source

SFPQ/S100A8 complex induces filaggrin deficiency via selective autophagy and JNK phosphorylation in atopic dermatitis. [PDF]

Cell Commun Signal
Kim G, Hong Y, Han TY, Han B, Park BS, Yang EJ, Kashif A, Jun YJ, An H, Lee J, Lee JS, Kim IS.   +11 more
europepmc   +1 more source

CXCR5 regulates CD8⁺/GZMB⁺ T cell infiltration and apoptotic signaling in breast cancer. [PDF]

iScience
Feng W, Yan J, Gong X, Hu J, Jin M, Ma C, Li F.   +6 more
europepmc   +1 more source