Results 291 to 300 of about 262,074 (332)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Epidermal PAR2‐TRPV3‐IL‐33 Signaling Promotes Mast Cell Recruitment and Sensory Nerve‐Mast Cell Interactions in Atopic Dermatitis

Allergy, EarlyView.
Jiahui Zhao, Lingxuan Zhou, Chenyu Wang, Ziyan Rao, Xiaohui Yuan, Jun Cui, Dongyu Zhao, Ying Sun, Yan Chen, Ruoyu Li, Miao Jing   +10 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Curcumin induces apoptosis in osteosarcoma cells by regulating the glycolytic pathway via the MAPK axis: a mechanistic study. [PDF]

Open Life Sci
Wang Y, Zhang Y, Zhang Y, Zhao J, Liao J, Luo J, Chen M, Peng P.   +7 more
europepmc   +1 more source

VNUT-mediated ATP release suppresses T helper 1 (T _H 1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade

Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen   +4 more
openalex   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Nicotinamide mononucleotide and nicotinamide riboside attenuate cytokine production in human keratinocytes via suppression of p38 Pathway. [PDF]

Mol Biol Rep
Xie C, Velandia MAM, Marecek S, Khalil M, Hao J.   +4 more
europepmc   +1 more source

Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway. [PDF]

Am J Transl Res
Wen D, Deng Q, Zeng Y, Li L, Yang X, Chen Q, Yan Y, Lv J.   +7 more
europepmc   +1 more source

The Synergistic Effects of Fine Particulate Matter and High Humidity on Allergic Asthma: An Association with TRPV4/MAPK Pathway Activation. [PDF]

Toxics
Shu Z, Yang X, Li B, Ma P, Wu Y, Li Y, Guo M, Du C, Fang F, Yao R.   +9 more
europepmc   +1 more source