Results 291 to 300 of about 297,973 (327)

JNK signaling in cancer cell survival

Medicinal research reviews (Print), 2019
c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival.
Qinghua Wu, Wenda Wu, Bishi Fu, Lei Shi, Xu Wang, K. Kuča   +5 more
semanticscholar   +1 more source

JNK Slowdown

Science Signaling, 2009
The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain.
openaire   +1 more source

The JNK signal transduction pathway

Current Opinion in Genetics & Development, 2002
The c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding of the physiological function of the JNK pathway. Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival ...
Claire R, Weston, Roger J, Davis
openaire   +3 more sources

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

Molecular and Cellular Neuroscience, 2012
Kainic acid (KA) induced seizures provokes an extensive neuronal degeneration initiated by c-Jun N-terminal kinases (JNK) as central mediators of excitotoxicity. However, the actions of their individual isoforms in cellular organelles including mitochondria remain to be elucidated.
Zhao Y, SPIGOLON, GIADA, Bonny C, Culman J, VERCELLI, Alessandro, Herdegen T.   +5 more
openaire   +3 more sources

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Science, 1995
Z. Xia, M. Dickens, J. Raingeaud, R. Davis, M. Greenberg   +4 more
semanticscholar   +1 more source

A central role for JNK in obesity and insulin resistance

Nature, 2002
J. Hirosumi, Gurol Tuncman, Lufen Chang, Cem Z. Görgün, K. Uysal, K. Maeda, M. Karin, G. Hotamisligil   +7 more
semanticscholar   +1 more source

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Science, 2002
G. Johnson, R. Lapadat
semanticscholar   +1 more source

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Science, 2000
F. Urano, Xiaozhong Wang, A. Bertolotti, Yuhong Zhang, Peter Chung, H. Harding, D. Ron   +6 more
semanticscholar   +1 more source

Signal integration by JNK and p38 MAPK pathways in cancer development

Nature Reviews. Cancer, 2009
E. Wagner, A. Nebreda
semanticscholar   +1 more source

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Science, 1997
H. Ichijo, E. Nishida, K. Irie, P. Dijke, M. Saitoh, T. Moriguchi, M. Takagi, Kunihiro Matsumoto, K. Miyazono, Y. Gotoh   +9 more
semanticscholar   +1 more source