Results 41 to 50 of about 297,973 (327)

Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives were designed and synthesised as selective inhibitors of JNK3, a target for the treatment of neurodegenerative diseases.
Youri Oh, Miyoung Jang, Hyunwook Cho, Songyi Yang, Daseul Im, Hyungwoo Moon, Jung-Mi Hah   +6 more
doaj   +1 more source

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]

, 2003
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio, Marinissen, Maria Julia, Offermanns, Stefan, Servitja, Joan-Marc, Simon, Melvin I.   +4 more
core   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2021
Chu-Yun Liu,1 Jian-Hua Wu,1 Zhi-Yuan Chen,1 Yi Zhang,1 Chun-Ling Huang,2 Ai-Mei Lin,1 Xiao-Ting Xu,1 Xiao-Hua Gao1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]

, 2012
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
A Barbarulo, A Chaidos, A Karadimitris, A Rahemtulla, AJ Bardwell, C Bubici, C-H Yoon, CG Pham, CR Geest, D Chauhan, D O Haskard, E Spanoudakis, EF Wagner, F Bost, F Zazzeroni, F Zhan, F Zhan, G Franzoso, H Ke, H Ke, J Cui, J Cui, J Ford, J Liu, K Kim, K Naresh, K Pruitt, K Sabapathy, KC Anderson, KN Naresh, L Aravind, L Hui, LC Platanias, M Anbalagan, M Blonska, M Gururajan, M Hallek, M Raman, M Wiznerowicz, MA Bogoyevitch, MA Bogoyevitch, MS Raab, N Chen, NJ Kennedy, NN Gangopadhyay, RT Nitta, S Goenka, S Goenka, S Papa, S Papa, SH Cho, SH Cho, SU Ahmed, SV Rajkumar, T Hideshima, T Hideshima, T Hideshima, T Kajiguchi, T Yanagawa, TE Witzig, V Brune, V Iansante, V Schreiber, YM Yang   +63 more
core   +2 more sources

OSR1 suppresses acute myeloid leukaemia cell proliferation by inhibiting LGR5-mediated JNK signalling

Autoimmunity, 2021
Odd-skipped related transcription factor 1 (OSR1) is implicated in various pathophysiologic processes, such as embryonic heart and urogenital formation, and functions as a tumour suppressor in diverse tumours.
Lingyan Zong, Yingxin Sun
doaj   +1 more source

On Probabilistic Applicative Bisimulation and Call-by-Value $\lambda$-Calculi (Long Version) [PDF]

, 2014
Probabilistic applicative bisimulation is a recently introduced coinductive methodology for program equivalence in a probabilistic, higher-order, setting. In this paper, the technique is applied to a typed, call-by-value, lambda-calculus.
C. Shannon, D. Comaniciu, D.J. Howe, F. Breugel van, G. Berry, G.D. Plotkin, J. Desharnais, J. Goubault-Larrecq, K.G. Larsen, S. Goldwasser, U. Lago Dal, V. Danos   +11 more
core   +4 more sources

Reovirus Infection Activates JNK and the JNK-Dependent Transcription Factor c-Jun [PDF]

Journal of Virology, 2001
ABSTRACT Viral infection often perturbs host cell signaling pathways including those involving mitogen-activated protein kinases (MAPKs). We now show that reovirus infection results in the selective activation of c-Jun N-terminal kinase (JNK).
P, Clarke, S M, Meintzer, C, Widmann, G L, Johnson, K L, Tyler   +4 more
openaire   +2 more sources