Results 71 to 80 of about 297,973 (327)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Applied Sciences, 2022 In this study, the CO2 sorption mechanisms and regeneration properties of alumina-based sorbent using K2CO3 loading under high-pressure and moderate temperature conditions were examined.
Do-Yeong Ryu +10 more
doaj +1 more source
A Study of Truck Platooning Incentives Using a Congestion Game [PDF]
, 2014 We introduce an atomic congestion game with two types of agents, cars and trucks, to model the traffic flow on a road over various time intervals of the day. Cars maximize their utility by finding a trade-off between the time they choose to use the road,
Farokhi, Farhad, Johansson, Karl H.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cells, 2019 Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ.
Anders Sundqvist +10 more
doaj +1 more source
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]
, 2017 KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara +7 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Promoting Truthful Behaviour in Participatory-Sensing Mechanisms [PDF]
, 2015 In this paper, the interplay between a class of nonlinear estimators and strategic sensors is studied in several participatory-sensing scenarios. It is shown that for the class of estimators, if the strategic sensors have access to noiseless measurements
Cantoni, Michael +2 more
core +2 more sources
JNK-signaling: A multiplexing hub in programmed cell death
Genes & cancer, 2017 Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling events underlying tumorigenesis and tumor progression.
Danny N. Dhanasekaran, E. Reddy
semanticscholar +1 more source
Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids [PDF]
The EMBO Journal, 2003 Inhibition of the c-Jun N-terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP-1 repression. GC antagonism of AP-1 relies mainly on the transrepression function of the GC receptor (GR) and mediates essential physiological and pharmacological actions.
Alejandra, Bruna +4 more
openaire +3 more sources