Results 71 to 80 of about 262,074 (332)

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]

, 2014
The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna, Haegeman, Guy, Heyninck, Karen, Looi, Chung Yeng, Mustafa, Ali Mohd, Mustafa, Mohd Rais   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Cells, 2019
Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ.
Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma- van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam   +10 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Promoting Truthful Behaviour in Participatory-Sensing Mechanisms [PDF]

, 2015
In this paper, the interplay between a class of nonlinear estimators and strategic sensors is studied in several participatory-sensing scenarios. It is shown that for the class of estimators, if the strategic sensors have access to noiseless measurements
Cantoni, Michael, Farokhi, Farhad, Shames, Iman   +2 more
core   +2 more sources

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids [PDF]

The EMBO Journal, 2003
Inhibition of the c-Jun N-terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP-1 repression. GC antagonism of AP-1 relies mainly on the transrepression function of the GC receptor (GR) and mediates essential physiological and pharmacological actions.
Alejandra, Bruna, Marta, Nicolàs, Alberto, Muñoz, John M, Kyriakis, Carme, Caelles   +4 more
openaire   +3 more sources

Nano‐Engineered Titanium Implants Loaded With Gingival Fibroblasts‐Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo

Advanced Healthcare Materials, EarlyView.
Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han, Chun Liu, Anjana Jayasree, Kamil Sokolowski, Andrew Liaw, Dingbin Liu, Carlos Salomon, Karan Gulati, Ryan SB Lee, Baoxin Huang, Sašo Ivanovski   +10 more
wiley   +1 more source

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation

International Journal of COPD, 2021
Zhi-yuan Chen,1 Yi Zhang,1 Jian-hua Wu,1 Xiao-hua Gao,1 Chun-ling Huang,2 Yu-mei Lin,1 Xiao-ting Xu,1 Yan Li1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y   +7 more
doaj  

Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep [PDF]

, 2018
Additional file 6: Decreased lag-2 function does not slow vulval development. The progeny of wild type and lag-2(q420) animals raised at 25.5 °C were selected at the L4 stage, prior to lethargus entry. Vulval eversion was scored after 3 h; the percentage
Bennett, Heather L, Biron, David, Hart, Anne C, Hayden, Dustin, Huang, Huiyan, Khoruzhik, Yulia, Sanders, Jarred, Walsh, Melissa B   +7 more
core   +4 more sources

The functional contrariety of JNK [PDF]

Molecular Carcinogenesis, 2007
AbstractThe JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been reported to have a role in the induction of apoptosis, but have also been implicated in enhancing cell survival and proliferation. Thus the JNK proteins seem to represent an archetype of
Ann M, Bode, Zigang, Dong
openaire   +2 more sources