Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7) [PDF]
Journal of Biological Chemistry, 1997 Mitogen-activated protein kinase (MAPK) kinases (MKKs) are dual-specificity protein kinases that phosphorylate and activate MAPK. We have isolated a cDNA encoding a novel protein kinase that has significant homology to MKKs.
Zhengbin Yao +12 more
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P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages. [PDF]
Front Immunol, 2019 Nayak TK +8 more
europepmc +3 more sources
Journal of Reproduction and Development, 2009 After reaching metaphase II, in vitro matured oocytes undergo the complex processes referred to as oocyte aging. Under our culture conditions, some aged oocytes remained at the stage of metaphase II, some underwent spontaneous parthenogenetic activation and others underwent cellular death, either through apoptosis (fragmentation) or lysis.
I. A. Petrova +9 more
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Biomedicines, 2022 Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and metabolic ...
Robert W. M. Min +4 more
doaj +1 more source
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. [PDF]
PLoS ONE, 2016 Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death.
Anna Ju +8 more
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The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
Cells, 2020 The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival ...
Manel B. Hammouda +3 more
doaj +1 more source
MAPK immunoreactivity in streptozotocin-induced diabetic rat testis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes.
Yelız Bozdemır Donmez +2 more
doaj +1 more source
DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine. [PDF]
PLoS ONE, 2014 Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a poor prognosis that is characterized by excessive mitogenic pathway activation and marked chemoresistance to a broad spectrum of chemotherapeutic drugs.
Fang Liu +3 more
doaj +1 more source
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
Nature Communications, 2020 The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential ...
Klára Kirsch +13 more
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