Results 41 to 50 of about 167,044 (343)

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Bogoyevitch, Endo, Genersch, Kyriakis, Lai, Moll, Numazawa, Ries, Ries, Schonbeck, Van den Steen, Waetzig, Westermarck, Yu   +13 more
core   +1 more source

Pyrus ussuriensis Maxim 70% ethanol eluted fraction ameliorates inflammation and oxidative stress in LPS‐induced inflammation in vitro and in vivo

Food Science &Nutrition, Volume 11, Issue 1, Page 458-469, January 2023., 2023
In this work, we demonstrated that PUM70 specifically suppressed LPS‐mediated inflammatory responses. Notably, PUM70 treatment inhibited LPS‐induced lung damage, pro‐inflammatory cytokine production, and reduced macrophage infiltration in the lungs. Mechanistically, PUM70 suppressed LPS‐induced inflammation and oxidative stress via the Nrf2/HO‐1 and ...
Fei Peng, Xin Ren, Bin Du, Yuedong Yang
wiley   +1 more source

Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation [PDF]

, 2005
Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we
Başağa, Hüveyda, Harris, P., Kütük, Özgür, Pedrech, A.   +3 more
core   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target

Therapeutic Advances in Medical Oncology, 2019
One of the mitogen-activated protein kinases (MAPKs), c-Jun NH2-terminal protein kinase (JNK) plays an important role in regulating cell fate, such as proliferation, differentiation, development, transformation, and apoptosis.
Jae Gwang Park, Nur Aziz, Jae Youl Cho
doaj   +1 more source

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]

, 2010
The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Data on the phosphorylation of p38MAPK and JNK induced by chlorpyrifos in Drosophila melanogaster

Data in Brief, 2016
Exposure to organophosphate compounds, such as chlorpyrifos, has been linked to disturbances on cell signaling pathways. Mitogen activated protein kinases (MAPK) are a family of protein kinases involved in a range of cellular processes, including stress ...
J.E.S. Batista, L.R. Sousa, I.K. Martins, N.R. Rodrigues, T. Posser, J.L. Franco   +5 more
doaj   +1 more source

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]

PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv   +1 more source

Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7 [PDF]

, 1997
Activation of jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) by interleukin-1 (IL-1) has been reported in many cells and in rabbit liver.
Cooper, J, Finch, A, Holland, P, Kracht, M, Saklatvala, J   +4 more
core   +1 more source