Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]
, 2014 Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre +67 more
core +2 more sources
Journal of Ginseng Research, 2021 Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan +8 more
doaj +1 more source
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]
, 2003 Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio +4 more
core +1 more source
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)
Journal of Biological Chemistry, 1995 AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The composition, the level and the activity of AP1 complexes are regulated in response to extracellular stimuli. An important role
M. Karin
semanticscholar +1 more source
Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]
, 2014 BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L +3 more
core +3 more sources
Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012 CXCL10 (IP10) is involved in mast cell migration to airway smooth muscle (ASM) bundles in asthma. We aimed to investigate the role of cytokine-induced MAPK activation in CXCL10 production by ASM cells from people with and without asthma. Confluent growth-arrested ASM cells were treated with inhibitors of the MAPKs ERK, p38, and JNK and transcription ...
Alrashdan, YA +10 more
openaire +4 more sources
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]
, 2016 The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S. +3 more
core +1 more source
BMC Neuroscience, 2013 Background The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases.
Zhu JianXi +7 more
doaj +1 more source
Role of JNK signaling in oral cancer: A mini review
Tumor Biology, 2017 JNKs (c-Jun N-terminal kinases) belong to mitogen-activated protein kinases’ family and become activated by several growth factors, stress, radiation, and other extracellular signals.
Ioannis Gkouveris, Nikolaos G Nikitakis
doaj +1 more source
Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology
International Journal of Molecular Sciences, 2018 Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts.
Kyunghee Lee +3 more
semanticscholar +1 more source