Results 31 to 40 of about 151,522 (216)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Gender, work, and satisfaction: a decomposition approach to job satisfaction gaps in Egypt and Tunisia

Frontiers in Sociology
IntroductionThis study revisits the paradox of the contented female worker by analyzing gender disparities in job satisfaction in Egypt and Tunisia.MethodsUsing nationally representative labor force survey data, we construct a multidimensional job ...
Mesbah Fathy Sharaf, Abdelhalem Mahmoud Shahen   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

THE ROLE OF HUMAN RESOURCES MANAGEMENT ON EMPLOYEE SATISFACTION OF PT. PANIN DUBAI SDAYA BANK

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
This study aims to determine how the role of human resource management on employee job satisfaction in supporting organizational performance. With an empirical approach and using field studies, this research seeks to find out information about the ...
Budiono I N., Aris
doaj   +1 more source

Parkinson's disease and the welding job: are both related?

Universa Medicina, 2020
Up to the present, there has been a controversy on the relationship between Parkinson’s disease and the welding job. The aim of this study was to obtain evidence-based information regarding the relationship between Parkinson’s disease and the welding job
Iqbal Mochtar, Muchtaruddin Mansyur
doaj   +1 more source

Exploring the optimum pattern for knowledge workers selection using DEA and CART compilation approach [PDF]

مدیریت تولید و عملیات, 2019
The success or failure of any organization is directly linked to the quality of its human resources selection (recruitment, measurement, and selection).
Maryam Akhavan Kharazian, Mohammad Mahdi Shahbazi, Mohammad Fatehi   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source