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JAMA Neurol
europepmc   +1 more source

Humoral response to John Cunningham virus during pregnancy in multiple sclerosis [PDF]

Multiple Sclerosis and Related Disorders, 2018
Pregnancy induces an immunosuppressive state in the mother to ensure immunological acceptance of the foetus. Impairment of cell-mediated immune responses may render the mother susceptible to intracellular pathogens. It is not presently known whether pregnancy alters the immunosurveillance for John Cunningham virus (JCV), an opportunistic pathogen ...
Maija Saraste, Saija Hurme
exaly   +5 more sources

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Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients

JAMA Neurology, 2017
Although seroepidemiological studies indicate that greater than 50% of the population has been infected with John Cunningham virus (JCV), the sites of JCV persistence remain incompletely characterized.To determine sites of JCV persistence in immunologically healthy individuals.Tissue specimens from multiple sites including brain, renal, and nonrenal ...
Joseph R Berger, Craig Miller, Elizabeth B Norton   +2 more
exaly   +3 more sources

Considerations on the appropriateness of the John Cunningham virus antibody assay use in patients with rheumatoid arthritis

Seminars in Arthritis and Rheumatism, 2015
The John Cunningham virus (JCV) is a generally benign and asymptomatic polyomavirus. Due to an association of the anti-integrin agent natalizumab with progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS), a newly developed anti-JCV antibody assay has been implemented as a risk-stratification tool for natalizumab ...
Joel M Kremer
exaly   +3 more sources

John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients

European Journal of Neurology, 2017
Background and purposeInfection with the John Cunningham virus (JCV) is required for the development of progressive multifocal leukoencephalopathy, the feared complication of natalizumab treatment in multiple sclerosis patients. The JCV seroconversion rate seems higher in natalizumab treated patients than in the normal population, with an unknown cause.
Zoé van Kempen, Theo Rispens, Joep Killestein   +2 more
exaly   +4 more sources

John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis

European Neurology, 2020
Introduction: Presence of anti-JC-virus antibodies (JCVAbs) is associated with the increased risk of natalizumab (NAT)-related progressive multifocal leukoencephalopathy (PML). Little is known about seroconversion rate and time to seroconversion in relapsing-remitting multiple sclerosis (RRMS) patients treated with NAT in Poland.
Katarzyna Kapica-Topczewska, Francois Collin, Joanna Tarasiuk, Agata Czarnowska, Monika Chorąży, Anna Mirończuk, Jan Kochanowicz, Alina Kułakowska   +7 more
openaire   +2 more sources

Monitoring the John Cunningham virus throughout natalizumab treatment in multiple sclerosis patients

European Journal of Neurology, 2015
Background and purposeProgressive multifocal leukoencephalopathy (PML) cases have arisen amongst multiple sclerosis patients treated with natalizumab. Our objective was to gain a better understanding of the mechanisms that underlie the John Cunningham virus (JCV) infection which causes PML.MethodsA study was made of (i) the quarterly JCV DNA levels in ...
M I, Domínguez-Mozo, M, García-Montojo, A, Arias-Leal, Á, García-Martínez, J L, Santiago, I, Casanova, V, Galán, R, Arroyo, M, Fernández-Arquero, R, Alvarez-Lafuente   +9 more
openaire   +2 more sources

Amino Acid Uptake, Glucose Metabolism, and Neuroinflammation in John Cunningham Virus Associated Progressive Multifocal Leukoencephalopathy

Clinical Nuclear Medicine, 2022
Abstract A 69-year-old woman presented with progressive dysarthria and cognitive deficits. On MRI, a T2-hyperintense, non–contrast-enhancing lesion was found in the left precentral area. 18F-FET and 18F-FDG PET scans revealed faint amino acid uptake and glucose hypometabolism of the lesion.
Marcus, Unterrainer, Christoph, Mahler, Adrian-Minh, Schumacher, Viktoria, Ruf, Bernhard, Blum, Stefanie, Quach, Matthias, Brendel, Rainer, Rupprecht, Peter, Bartenstein, Martin, Kerschensteiner, Tania, Kümpfel, Nathalie L, Albert   +11 more
openaire   +2 more sources

Potential of Carcinogenesis Induced by John-Cunningham Virus and Crude-Oil Extracts [PDF]

International Archives of Medical Microbiology, 2018
Lin Shih-Chao, Lien Christopher Z, Lin Chi-Chen   +2 more
exaly   +2 more sources

Analysis of John Cunningham Virus DNA in Immunosuppressed Patients

2023
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by John Cunningham Virus (JCV). JCV is rarely pathogenic in immunocompetent individuals but can reactivate in immunosuppressed patients and cause PML. This study aimed to analyze JCV DNA in immunosuppressed patients by quantitative real-time
KIRCA, Füsun, DİNÇ, Bedia
openaire   +1 more source