Results 21 to 30 of about 5,814 (145)

Unveiling the Enigma: John Cunningham Virus-Associated Progressive Multifocal Leukoencephalopathy in an Immunocompetent Individual. [PDF]

Cureus
Progressive multifocal leukoencephalopathy (PML) is considered an often fatal, demon-leading disease primarily associated with immunosuppression. Immunocompromised individuals predominantly exhibit this manifestation, while immunocompatible patients rarely encounter it.
Arumugam P, Singh L, Agarwal P, Shetti S, Sharan S.   +4 more
europepmc   +3 more sources

High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis. [PDF]

J Clin Neurol, 2019
The anti-John-Cunningham virus (JCV)-antibody serostatus and index are used in the risk stratification of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients treated with natalizumab. However, little information on these parameters is available for Asian countries.
Kim SH, Kim Y, Jung JY, Park NY, Jang H, Hyun JW, Kim HJ.   +6 more
europepmc   +4 more sources

Real-world treatment outcomes and safety of natalizumab in Finnish multiple sclerosis patients

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2023
Objectives The primary objective was to evaluate long-term treatment persistence and safety of natalizumab in Finnish multiple sclerosis patients. The secondary objectives were to assess patient characteristics, use of natalizumab-related safety protocol,
Auli Verkkoniemi-Ahola, Päivi Hartikainen, Katja Hassi, Hanna Kuusisto, Sanni Lahdenperä, Juha Mehtälä, Matias Viitala, Tero Ylisaukko-oja, Merja Soilu-Hänninen   +8 more
doaj   +1 more source

Mapping the history and current situation of research on John Cunningham virus - a bibliometric analysis. [PDF]

BMC Infect Dis, 2009
John Cunningham virus (JCV) constitutes a family of polyoma viruses, which plays important roles in the progressive multifocal leukoencephalopathy (PML) and tumorigenesis. However, no bibliometric investigation has been reported to guide the researchers and potential readers.Papers were collected from database Sci-expanded and Pubmed until May 22, 2008.
Zheng HC, Yan L, Cui L, Guan YF, Takano Y.   +4 more
europepmc   +5 more sources

Kidney Allograft Dysfunction Due to John Cunningham (JC) Virus Nephropathy

Cureus, 2022
John Cunningham (JC) polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of polyomavirus-associated nephropathy (PVAN). Although BK polyomavirus (BKPyV) is a relatively proven common infection post kidney transplantation, JC polyomavirus (JCPyV) infection and its impact on graft function have been less studied.
Sharma, Neeraj, Abdulkhalek, Samer
openaire   +2 more sources

Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment. [PDF]

Biomedicines
Background/Objectives: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite the observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk of developing progressive multifocal leukoencephalopathy (PML).
García S, García-Martell A, Quiñones-Aguilar S, Sauri-Suárez S, Téllez González MA, García-Castillo G, Suárez-Cuenca JA, Toledo-Lozano CG, Mondragón Terán P, Alcaraz-Estrada SL.   +9 more
europepmc   +4 more sources

Cerebral lesions in hematological malignancies: a case report

Journal of Medical Case Reports, 2021
Background Progressive multifocal leukoencephalopathy is a rare central nervous system disease, resulting from reactivation of latent John Cunningham virus.
Nicoletta D’Ettore, Valentina Scheggi, Brunetto Alterini, Niccolò Marchionni   +3 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report

Journal of Medical Case Reports, 2022
Background Progressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes and, to a lesser extent, to astrocytes’ response to human neurotrophic John Cunningham polyomavirus ...
Sima Bahrami, Saba Arshi, Mohammad Nabavi, Mohammad Hassan Bemanian, Morteza Fallahpour, Afshin Rezaeifar, Sima Shokri   +6 more
doaj   +1 more source

HIGH PREVALENCE OF JOHN CUNNINGHAM VIRURIA IN RENAL TRANSPLANT RECIPIENTS

The Iraqi Journal of Medical Sciences, 2017
Background: John Cunningham virus (JCV) is one of the important viruses in immunocompromised patients. High JC viruria is seen in kidney allograft recipients; some of them with a polyomavirus associated nephropathy (PVAN) just like BK polyomavirus but to
Mervit B. Jasim, Ali J.H. Al-Saedi, Mustafa R. Hussein, Asmaa B. Al-Obaidi, Haider S. Kadhim   +4 more
doaj   +6 more sources

Accuracy of New John Cunningham Virus Antibody Assay in Natalizumab-Treated Patients With Multiple Sclerosis.

JAMA Neurol
This cross-sectional study examines the increase in positive results for John Cunningham virus antibodies and higher risk for progressive multifocal leukoencephalopathy among patients with multiple sclerosis receiving natalizumab.
Gelissen LMY, Wijburg MT, Strijbis EMM, van Oosten BW, de Jong BA, Uitdehaag BMJ, Rispens T, Feltkamp MCW, van Kempen ZLE, Killestein J.   +9 more
europepmc   +3 more sources