Results 51 to 60 of about 307,462 (308)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Wear prediction for dry revolute joint with clearance in multibody system by integrating dynamics model and wear model

Latin American Journal of Solids and Structures
This work presents an investigation on wear prediction of multibody system including dry revolute clearance joint using a computational methodology. A procedure to analyze multibody system in which wear is present at revolute joints is presented.
Z.F. Bai, H.B. Zhang, Y. Sun
doaj   +1 more source

Analysis of dynamic characteristics for momentum wheel assembly with joint clearance

Advances in Mechanical Engineering, 2018
To study the effects of joint clearance on the dynamic characteristics of the momentum wheel assembly of satellite antennas, the computational dynamic model of momentum wheel assembly is developed in this article, considering influencing factors ...
Qi Wan, Geng Liu, Haitao Shi, Xiaofeng Zhang, Xin Ning   +4 more
doaj   +1 more source

Multiscale modelling of fluid and solute transport in soft tissues and microvessels [PDF]

, 2010
This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several ...
Lu, Yiling, Wang, Wen
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

含运动副间隙的双万向节系统动力学研究

Jixie chuandong, 2012
The solid model of the system of double cardan joint is built through Pro/Engineer,then it is imported into ADAMS to take the dynamic simulation analysis.For the model which does not contain joint clearance,the proper restrain is added according to ...
张辉, 葛文杰, 宁方立, 赵炜
doaj  

Adhesion and surface forces in polymer tribology—A review

Friction, 2018
Polymer tribology is a fast growing area owing to increasing applications of polymers and polymer composites in industry, transportation, and many other areas of economy.
Nikolai Myshkin, Alexander Kovalev
doaj   +1 more source

Dynamic analysis of a parallel robot with spherical joints with consideration for joint clearance

Nihon Kikai Gakkai ronbunshu, 2022
This paper proposes a dynamic analysis method for evaluating the vibrational behavior of a parallel robot having spherical joints with clearance. By using variables that represent the relative displacement between the elements of clearance joints as ...
Masumi OHNO, Yukio TAKEDA
doaj   +1 more source

A Biopersistence Study following Exposure to Chrysotile Asbestos Alone or in Combination with Fine Particles [PDF]

, 2008
In designing a study to evaluate the inhalation biopersistence of a chrysotile asbestos that was used as a component of a joint-compound, a feasibility study was initiated to evaluate the short-term biopersistence of the chrysotile alone and of the ...
Bernstein D. M., Bernstein D. M., Bernstein D. M., Bernstein D. M., Bernstein D. M., Bernstein D. M., Bolton R. E., Brorby G. P., Cossette M., D. M. Bernstein, Hass A., Hesterberg T. W., Hesterberg T. W., Hume L. A., J. Chevalier, K. Donaldson, Muhle H., Musselman R. P., Oberdorster G., Oberdorster G., P. Kunzendorf, Pundsack F. L., S. E. Holm, S. Gaering, Schaible U. E., Silver I. A., Skinner H. C.W., U. Decker, World Health Organization   +28 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source