Results 31 to 40 of about 20,657 (229)

BET Protein Inhibitor JQ1 Modulates Mitochondrial Dysfunction and Oxidative Stress Induced by Chronic Kidney Disease

Antioxidants, 2023
Among the mechanisms involved in the progression of kidney disease, mitochondrial dysfunction has special relevance. Epigenetic drugs such as inhibitors of extra-terminal domain proteins (iBET) have shown beneficial effects in experimental kidney disease,
Sandra Rayego-Mateos, Pamela Basantes, José Luis Morgado-Pascual, Beatriz Brazal Prieto, Beatriz Suarez-Alvarez, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega   +7 more
doaj   +1 more source

Co-administration of JQ1, a bromodomain-containing protein 4 inhibitor, enhances the antitumor effect of combretastatin A4, a microtubule inhibitor, while attenuating its cardiotoxicity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Combretastatin A4 (CA4) inhibits microtubule polymerization, and clinical trials of the prodrug, CA4 disodium phosphate (CA4DP), as an anti-cancer agent have been conducted.
Haruka Orihara, Min Ma, Yoshiyasu Nagashima, R. Tochinai, S. Sekizawa, Daiki Kato, M. Shinada, Susumu Aoki, N. Fujita, T. Nakagawa, Yoshiharu Tsuru, Y. Tatewaki, T. Mutoh, Yasuyuki Taki, R. Nishimura, Masayoshi Kuwahara   +15 more
semanticscholar   +1 more source

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]

, 2013
Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina, Beckers, Anneleen, Eggert, Angelika, El-Hindy, Nicolai, Fleischhack, Gudrun, Henssen, Anton, Heukamp, Lukas, Odersky, Andrea, Schramm, Alexander, Schulte, Johannes H, Schäfers, Simon, Speleman, Franki, Sure, Ulrich, Thor, Theresa   +13 more
core   +4 more sources

JQ1 attenuates contrast-induced acute kidney injury through the upregulation of autophagy and inhibition of inflammation

International Urology and Nephrology, 2023
Purpose Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired AKI. However, there is a paucity of efficacious interventions for the management of CI-AKI. Here, we aim to investigate the effects of JQ1 in CI-AKI
Linghong Ge, Juntao Chen, Xueying Ren, Chunqi Huang, Danqing Dong, Zhou Yin   +5 more
semanticscholar   +1 more source

BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1 [PDF]

, 2013
The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several hematological cancers, notably mixed lineage leukemia-fusion acute myeloid ...
Bastow, Sarah, Chevassut, Timothy James Telfer, Horne, Gillian Abigail, Stewart, Helen Jayne Susan   +3 more
core   +1 more source

Metabolic Reprogramming by Ribitol Expands the Therapeutic Window of BETi JQ1 against Breast Cancer

Cancers, 2023
Simple Summary Safety and pre-existing or acquired resistance to treatments limit the clinical benefit of most drugs against breast cancer. Great effort has been made to mitigate the limitations of combined drug treatment.
Ravi Doddapaneni, J. Tucker, Pei J Lu, Qi L Lu   +3 more
semanticscholar   +1 more source

A novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

Cell Death and Disease, 2021
Bromodomain-containing protein 4 (BRD4) has emerged as a promising treatment target for bone-related disorders. (+)-JQ1, a thienotriazolodiazepine compound, has been shown to inhibit pro-osteoclastic activity in a BRD4-dependent approach and impede bone ...
Ying Liu, Wenjie Liu, Ziqiang Yu, Yan Zhang, Yinghua Li, Dantao Xie, Gang Xie, Li Fan, Shipeng He   +8 more
doaj   +1 more source

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments [PDF]

, 2013
Background: Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories.
Beckers, Anneleen, De Brouwer, Sara, Kumps, Candy, Leonelli, Carina, Mestdagh, Pieter, Mets, Evelien, Pattyn, Filip, Rihani, Ali, Rondou, Pieter, Speleman, Franki, Van der Meulen, Joni, Van Maerken, Tom, Van Peer, Gert, Vandesompele, Jo   +13 more
core   +4 more sources

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research, 2023
Bromodomain and extraterminal (BET) proteins are extensively studied in multiple pathologies, including cancer. BET proteins modulate transcription of various genes, including those synonymous with cancer, such as MYC.
Andrew D. Huber, Shyaron Poudel, Jing Wu, Darcie J. Miller, Wenwei Lin, Lei Yang, Monicah N Bwayi, Mary Ashley Rimmer, R. R. F. Gee, J. Seetharaman, S. Chai, Taosheng Chen   +11 more
semanticscholar   +1 more source

The effect of JQ1 systemic administration on oxidative stress and apoptotic markers in renal ischemic reperfusion injury in a rat model

Journal of Medicine and Life, 2023
This study aimed to investigate the effects of JQ1 in a renal ischemia-reperfusion (IR) rat model. Twenty-four adult male Wistar Albino rats were randomly divided into four equal groups.
Saba Sahib Younis, F. A. Ghafil, S. Majeed, N. Hadi   +3 more
semanticscholar   +1 more source