Results 71 to 80 of about 20,657 (229)

JQ1 Treatment and miR-21 Silencing Activate Apoptosis of CD44+ Oral Cancer Cells

International Journal of Molecular Sciences
Oral cancer ranks in the top 10 most prevalent malignancies worldwide. It is an aggressive tumor with frequent relapses and metastases and relatively modest survival rates that do not improve in spite of constantly evolving treatment modalities.
Milica Jakšić Karišik, M. Lazarević, Dijana D Mitić, Olivera Mitrovic Ajtic, G. Damante, Jelena M. Milašin   +5 more
semanticscholar   +1 more source

A triple-mode strategy on JQ1-loaded nanoplatform for superior antitumor therapy in pancreatic cancer

Materials Today Bio
Pancreatic cancer's dire prognosis urgently calls for innovative therapeutic strategies. JQ1, a bromodomain 4 inhibitor, exhibits potent anti-tumor activity in preclinical models but faces limitations due to rapid resistance development.
Zhiguo Li, Jinxin Duan, Zhiwen Liu, Weifan Li, Yiyin Mai, Hao Fu, Guotao Yuan, Jiawei Wang   +7 more
semanticscholar   +1 more source

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. [PDF]

PLoS ONE, 2016
Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.
Jude T Deeney, Anna C Belkina, Orian S Shirihai, Barbara E Corkey, Gerald V Denis   +4 more
doaj   +1 more source

Moduli of nodal curves on K3 surfaces [PDF]

, 2017
We consider modular properties of nodal curves on general $K3$ surfaces. Let $\mathcal{K}_p$ be the moduli space of primitively polarized $K3$ surfaces $(S,L)$ of genus $p\geqslant 3$ and $\mathcal{V}_{p,m,\delta}\to \mathcal{K}_p$ be the universal ...
Ciliberto, Ciro, Flamini, Flaminio, Galati, Concettina, Knutsen, Andreas Leopold   +3 more
core   +1 more source

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

eLife, 2017
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy
Fraser Aird, Irawati Kandela, Christine Mantis, Reproducibility Project: Cancer Biology   +3 more
doaj   +1 more source

On wireless connection between Josephson qubits

, 2009
By attributing a circulating Josephson current induced diamagnetic moment to a SQUID-type three-level qubit, a wireless connection between such qubits is proposed based only on dipole-dipole interaction between their moments.
Rotoli, Giacomo, Sergeenkov, Sergei
core   +1 more source

Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension [PDF]

, 2016
Background and objective Nuclear factor kappa B (NF-kB)-mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of the fatal disease, pulmonary arterial hypertension (PAH ...
Adcock, IM, Gambaryan, N, Humbert, M, Meng, C, Mumby, SE, Perros, F, Wort, SJ   +6 more
core   +1 more source

JQ1 is a potential therapeutic option for COPD patients with agrin overexpression [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2018
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and death worldwide. It is characterized by chronic pulmonary inflammation and obstructed airflow from the lungs. To date, there is no effective treatment for COPD. The activation of the agrin (AGRN-YAP pathway can promote heart regeneration. Because agrin can induce
Zhen, Xiao, Jing, Shu, Feng, Zhou, Yong, Han   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]

, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad, B. Tolani, Ballon, Benhamou, Bower, Bren, C. Graham, Chang, Chaudhary, Chugh, Delmore, Dong, Du, Dupin, Dupin, Eeva, Eeva, Field, Gerondakis, Guasparri, H. Matta, H. Yi, Hassman, Herzog, Lee, Liu, Madureira, Matta, Matta, Matta, Matta, Mineva, Nador, Niiro, P. M. Chaudhary, Parravicini, Punj, Schauer, Soulier, Sun, Sun, Sun, Thome, Vrzalikova, Waterston, Wu, Wu, Wu, Y. Suo, Y. Yang, Yang, Yang, Young, Zhao   +53 more
core   +1 more source