Results 11 to 20 of about 654 (107)

A Novel Jumbo Phage PhiMa05 Inhibits Harmful Microcystis sp. [PDF]

Frontiers in Microbiology, 2021
Microcystis poses a concern because of its potential contribution to eutrophication and production of microcystins (MCs). Phage treatment has been proposed as a novel biocontrol method for Microcystis.
Ampapan Naknaen, Oramas Suttinun, Oramas Suttinun, Komwit Surachat, Komwit Surachat, Eakalak Khan, Rattanaruji Pomwised   +6 more
doaj   +8 more sources

vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting Pseudomonas aeruginosa, Possesses Unusual Genomic Features [PDF]

Frontiers in Microbiology, 2019
Phages are the most abundant biological entity on Earth. There are many variants in phage virion sizes, morphology, and genome sizes. Large virion sized phages, with genome sizes greater than 200 kbp have been identified and termed as Jumbo phages. These
Mohammed Imam, Mohammed Imam, Bandar Alrashid, Bandar Alrashid, Faizal Patel, Ahmed S. A. Dowah, Nathan Brown, Andrew Millard, Martha R. J. Clokie, Edouard E. Galyov   +9 more
doaj   +7 more sources

The Phage Nucleus and PhuZ Spindle: Defining Features of the Subcellular Organization and Speciation of Nucleus-Forming Jumbo Phages [PDF]

Frontiers in Microbiology, 2021
Bacteriophages and their bacterial hosts are ancient organisms that have been co-evolving for billions of years. Some jumbo phages, those with a genome size larger than 200 kilobases, have recently been discovered to establish complex subcellular ...
Vorrapon Chaikeeratisak, Vorrapon Chaikeeratisak, Erica A. Birkholz, Joe Pogliano   +3 more
doaj   +5 more sources

Proteomic analysis of a novel Bacillus Jumbo phage revealing glycoside hydrolase as structural component [PDF]

Frontiers in Microbiology, 2016
Tailed phages with genomes of larger than 200 kbp are classified as Jumbo phages and exhibited extremely high uncharted diversity. The genomic annotation of Jumbo phage is often disappointing because most of the predicted proteins, including structural ...
Yihui eYuan, Meiying eGao
doaj   +5 more sources

Jumbo phage killer immune system targets early infection of nucleus-forming phages. [PDF]

Cell
Jumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and a proteinaceous nucleus-like structure during infection. These structures protect the phage from nucleases and may create selective pressure for immunity mechanisms targeting this specific phage family. Here, we identify "jumbo phage killer" (Juk),
Yuping L, Guan L, Becher I, Makarova KS, Cao X, Hareendranath S, Guan J, Stein F, Yang S, Boergel A, Lapouge K, Remans K, Agard D, Savitski M, Typas A, Koonin EV, Feng Y, Bondy-Denomy J.   +17 more
europepmc   +5 more sources

Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage. [PDF]

Sci Adv, 2022
Many eukaryotic viruses assemble mature particles within distinct subcellular compartments, but bacteriophages are generally assumed to assemble randomly throughout the host cell cytoplasm. Here, we show that viral particles of Pseudomonas nucleus-forming jumbo phage PhiPA3 assemble into a ...
Chaikeeratisak V, Khanna K, Nguyen KT, Egan ME, Enustun E, Armbruster E, Lee J, Pogliano K, Villa E, Pogliano J.   +9 more
europepmc   +7 more sources

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. [PDF]

Nucleic Acids Res
Abstract Large-genome bacteriophages (jumbo phages) of the proposed family Chimalliviridae assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and DNA-targeting CRISPR-Cas nucleases.
Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD.   +20 more
europepmc   +7 more sources

Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection. [PDF]

Cell Host Microbe
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly is unclear.
Mozumdar D, Fossati A, Stevenson E, Guan J, Nieweglowska E, Rao S, Agard D, Swaney DL, Bondy-Denomy J.   +8 more
europepmc   +6 more sources

Pseudomonas Phage PaBG—A Jumbo Member of an Old Parasite Family [PDF]

Viruses, 2020
Bacteriophage PaBG is a jumbo Myoviridae phage isolated from water of Lake Baikal. This phage has limited diffusion ability and thermal stability and infects a narrow range of Pseudomonas aeruginosa strains.
Peter Evseev, Nina Sykilinda, Anna Gorshkova, Lidia Kurochkina, Rustam Ziganshin, Valentin Drucker, Konstantin Miroshnikov   +6 more
doaj   +3 more sources

3D structure of three jumbo phage heads

Journal of General Virology, 2020
Jumbo phages are bacteriophages that carry more than 200 kbp of DNA. In this study we characterized two jumbo phages (ΦRSL2 and ΦXacN1) and one semi-jumbo phage (ΦRP13) at the structural level by cryo-electron microscopy. Focusing on their capsids, three-dimensional structures of the heads at resolutions ranging from 16 to 9 Å were calculated. Based on
Emmanuelle Neumann, Takeru Kawasaki, Grégory Effantin, Leandro F. Estrozi, Orawan Chatchawankanphanich, Takashi Yamada, Guy Schoehn   +6 more
openaire   +6 more sources