Results 51 to 60 of about 654 (107)

Selective transport of fluorescent proteins into the phage nucleus

PLoS ONE, 2021
Upon infection of Pseudomonas cells, jumbo phages 201Φ2–1, ΦPA3, and ΦKZ assemble a phage nucleus. Viral DNA is enclosed within the phage-encoded proteinaceous shell along with proteins associated with DNA replication, recombination and transcription ...
Katrina T. Nguyen, Joseph Sugie, Kanika Khanna, MacKennon E. Egan, Erica A. Birkholz, Jina Lee, Christopher Beierschmitt, Elizabeth Villa, Joe Pogliano   +8 more
doaj   +2 more sources

Isolation, Characterization and Genomic Analysis of a Novel Jumbo Phage, AerS_266, That Infects Aeromonas salmonicida

Microorganisms, 2023
Aeromonas salmonicida is the causative agent of septicemia in fish, and it is associated with significant economic losses in the aquaculture industry. While piscine Aeromonas infections are mainly treated with antibiotics, the emergence of resistance in ...
Vera Morozova, Igor Babkin, Yuliya Kozlova, Artem Tikunov, Tatiana Ushakova, Alevtina Bardasheva, Valeria Fedorets, Elena Zhirakovskaya, Nina Tikunova   +8 more
doaj   +1 more source

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

Nature Communications, 2023
To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show that the 2D crystal enclosing this so-called phage nucleus is an assembly of ...
Eliza S. Nieweglowska, Axel F. Brilot, Melissa Méndez-Moran, Claire Kokontis, Minkyung Baek, Junrui Li, Yifan Cheng, David Baker, Joseph Bondy-Denomy, David A. Agard   +9 more
doaj   +1 more source

Biological and Genomic Characterization of a Novel Jumbo Bacteriophage, vB_VhaM_pir03 with Broad Host Lytic Activity against Vibrio harveyi

Pathogens, 2020
Vibrio harveyi is a Gram-negative marine bacterium that causes major disease outbreaks and economic losses in aquaculture. Phage therapy has been considered as a potential alternative to antibiotics however, candidate bacteriophages require comprehensive
Gerald N. Misol, Constantina Kokkari, Pantelis Katharios   +2 more
doaj   +1 more source

Isolation and Characterization of Jumbo Coliphage vB_EcoM_Lh1B as a Promising Therapeutic Agent against Chicken Colibacillosis

Microorganisms, 2023
Colibacillosis in chickens can cause the death of young stock, decrease weight gain and lead to significant economic losses. Currently, antibiotic therapy is the main method of treatment of infected animals, but unchecked use of antibiotics has led to ...
Pavel Alexyuk, Andrey Bogoyavlenskiy, Madina Alexyuk, Kuralay Akanova, Yergali Moldakhanov, Vladimir Berezin   +5 more
doaj   +1 more source

Exploring pangenomic diversity and CRISPR-Cas evasion potential in jumbo phages: a comparative genomics study

Microbiology Spectrum
Jumbo phages are characterized by their remarkably large-sized genome and unique life cycles. Jumbo phages belonging to Chimalliviridae family protect the replicating phage DNA from host immune systems like CRISPR-Cas and restriction-modification system ...
Sharayu Magar, Vaishnavi Kolte, Gaurav Sharma, Sutharsan Govindarajan   +3 more
doaj   +1 more source

Differential Bacteriophage Efficacy in Controlling Salmonella in Cattle Hide and Soil Models

Frontiers in Microbiology, 2021
Asymptomatic Salmonella carriage in beef cattle is a food safety concern and the beef feedlot environment and cattle hides are reservoirs of this pathogen. Bacteriophages present an attractive non-antibiotic strategy for control of Salmonella in beef. In
Yicheng Xie, Yicheng Xie, Tyler Thompson, Chandler O’Leary, Chandler O’Leary, Stephen Crosby, Quang X. Nguyen, Mei Liu, Jason J. Gill, Jason J. Gill   +9 more
doaj   +1 more source

Characterization and genomic analysis of Sharanji: a jumbo bacteriophage of Escherichia coli

Virology Journal
Background Bacteriophages are the most genetically diverse biological entities in nature. Our current understanding of phage biology primarily stems from studies on a limited number of model bacteriophages.
Sharayu Magar, Sivaraj Barath, Debmitra Sen, Ranjith Kumar Singari, T. Nagarajan, Anjali Parmar, Sutharsan Govindarajan   +6 more
doaj   +1 more source

Structural studies of the nucleus-like assembly of jumbo bacteriophage 201φ2-1

Frontiers in Microbiology, 2023
The jumbo phages encode proteins that assemble to form a nucleus-like compartment in infected cells. Here we report the cryo-EM structure and biochemistry characterization of gp105, a protein that is encoded by the jumbo phage 201φ2-1 and is involved in ...
Zhe Liu, Ye Xiang
doaj   +1 more source

Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes. [PDF]

Sci Rep, 2018
Yoshikawa G, Askora A, Blanc-Mathieu R, Kawasaki T, Li Y, Nakano M, Ogata H, Yamada T.   +7 more
europepmc   +2 more sources