Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes. [PDF]
Sci Rep, 2018 Xanthomonas virus (phage) XacN1 is a novel jumbo myovirus infecting Xanthomonas citri, the causative agent of Asian citrus canker. Its linear 384, 670 bp double-stranded DNA genome encodes 592 proteins and presents the longest (66 kbp) direct terminal ...
Yoshikawa G +7 more
europepmc +2 more sources
Characterization of a novel genus of jumbo phages and their application in wastewater treatment
iScience, 2023 Phages widely exist in numerous environments from wastewater to deep ocean, representing a huge virus diversity, yet remain poorly characterized. Among them, jumbo phages are of particular interests due to their large genome (>200 kb) and unusual biology.
Ming Hu +17 more
openaire +3 more sources
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection
, 2023 Large-genome bacteriophages (jumbo phages) of the Chimalliviridae family assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases.
Eray Enustun +18 more
openaire +2 more sources
Nucleus-Forming Jumbo Phage: Disrupting the Landscape of Phage Replication and Viral Speciation [PDF]
, 2022 This dissertation investigates the diversity and competition of nucleus-forming jumbo phage. The first chapter provides a brief history of the discovery of bacteriophages and their early use to combat bacterial infections, the detection of the first ...
Birkholz, Erica Ann
core
Characterization and Genomic Analysis of PALS2, a Novel Staphylococcus Jumbo Bacteriophage
Frontiers in Microbiology, 2021 Staphylococcus aureus is an important human pathogen that can be frequently encountered in clinical and food-processing surroundings. Among the various countermeasures, bacteriophages have been considered to be promising alternatives to antibiotics.
Yoona Lee +9 more
doaj +1 more source
, 2023 Aeromonas hydrophila is an emerging foodborne pathogen causing human gastroenteritis. Aeromonas species isolated from food such as seafood presented multidrug-resistance (MDR), raising serious concerns regarding food safety and public health.
Yang Zhou (65942) +11 more
core +1 more source
Immediate targeting of host ribosomes by jumbo phage encoded proteins
, 2023 Abstract Bacteriophages must seize control of the host gene expression machinery to promote their own protein synthesis. Since the bacterial hosts are armed with numerous anti-phage defence systems, it is essential that mechanisms of host take-over act immediately upon infection.
Gerovac M +5 more
europepmc +2 more sources
Isolation and Characterization of a Novel Jumbo Phage HPP-Temi Infecting Pseudomonas aeruginosa Pa9 and Increasing Host Sensitivity to Ciprofloxacin. [PDF]
Antibiotics (Basel)Pseudomonas aeruginosa is a bacteria responsible for many hospital-acquired infections. Phages are promising alternatives for treating P. aeruginosa infections, which are often intrinsically resistant. The combination of phage and antibiotics in clearing
Olorundare OO +11 more
europepmc +2 more sources
The complex developmental mechanisms of nucleus-forming jumbo phages. [PDF]
Curr Opin MicrobiolBacteriophages related to the jumbo phage ΦKZ (Family: Chimalliviridae) exhibit a complex developmental cycle. First, two large macromolecular compartments are assembled that surround and protect the bacteriophage genome. Upon infection, the injected phage genomic DNA (gDNA) is rapidly enclosed within a lipid-based 'early phage infection (EPI) vesicle',
Mozumdar D, A Agard D, Bondy-Denomy J.
europepmc +4 more sources
Selective transport of fluorescent proteins into the phage nucleus
PLoS ONE, 2021 Upon infection of Pseudomonas cells, jumbo phages 201Φ2–1, ΦPA3, and ΦKZ assemble a phage nucleus. Viral DNA is enclosed within the phage-encoded proteinaceous shell along with proteins associated with DNA replication, recombination and transcription ...
Katrina T. Nguyen +8 more
doaj +2 more sources