Results 61 to 70 of about 654 (107)

The complex developmental mechanisms of nucleus-forming jumbo phages. [PDF]

Curr Opin Microbiol
Mozumdar D, A Agard D, Bondy-Denomy J.
europepmc   +2 more sources

The Biology of Nucleus-Forming Jumbo Phages

Annual Review of Genetics
Nucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucleus encloses phage DNA in a protein shell, strictly uncouples transcription from translation, and facilitates selective protein import and messenger RNA ...
Erica A. Birkholz, Emily G. Armbruster, Joe Pogliano   +2 more
openaire   +1 more source

The human oral phageome is highly diverse and rich in jumbo phages [PDF]

, 2020
AbstractUntil recently, the contribution of bacteriophages to the composition and function of the human microbiome has been largely overlooked. Recent developments in discovering novel bacteriophages from human metagenomes have been mostly focused on the gut.
Victoria R. Carr, Andrey Shkoporov, David Gomez-Cabrero, Peter Mullany, Colin Hill, David L. Moyes   +5 more
openaire   +1 more source

Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates

Journal of Biomedical Science
Background Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically and genetically and evaluated for ...
Paschalis Paranos, Dimitrios Skliros, Nikita Zrelovs, Panagiota-Christina Georgiou, Karina Svanberga, Andris Kazaks, Marios Kostakis, Nikolaos Thomaidis, Emmanouil Flemetakis, Joseph Meletiadis   +9 more
doaj   +1 more source

Population Dynamics between Erwinia amylovora, Pantoea agglomerans and Bacteriophages: Exploiting Synergy and Competition to Improve Phage Cocktail Efficacy

Microorganisms, 2020
Bacteriophages are viruses capable of recognizing with high specificity, propagating inside of, and destroying their bacterial hosts. The phage lytic life cycle makes phages attractive as tools to selectively kill pathogenic bacteria with minimal impact ...
Steven Gayder, Michael Parcey, Darlene Nesbitt, Alan J. Castle, Antonet M. Svircev   +4 more
doaj   +1 more source

Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages

Nature Communications
Jumbo phages are a group of tailed bacteriophages with large genomes and capsids. As a prototype of jumbo phage, ΦKZ infects Pseudomonas aeruginosa, a multi-drug-resistant (MDR) opportunistic pathogen leading to acute or chronic infection in ...
Yashan Yang, Qianqian Shao, Mingcheng Guo, Lin Han, Xinyue Zhao, Aohan Wang, Xiangyun Li, Bo Wang, Ji-An Pan, Zhenguo Chen, Andrei Fokine, Lei Sun, Qianglin Fang   +12 more
doaj   +1 more source

Klebsiella phage vB_KleM-RaK2 - a giant singleton virus of the family Myoviridae.

PLoS ONE, 2013
At 346 kbp in size, the genome of a jumbo bacteriophage vB_KleM-RaK2 (RaK2) is the largest Klebsiella infecting myovirus genome sequenced to date. In total, 272 out of 534 RaK2 ORFs lack detectable database homologues.
Eugenijus Simoliūnas, Laura Kaliniene, Lidija Truncaitė, Aurelija Zajančkauskaitė, Juozas Staniulis, Algirdas Kaupinis, Marija Ger, Mindaugas Valius, Rolandas Meškys   +8 more
doaj   +1 more source

Two asian jumbo phages, ϕRSL2 and ϕRSF1, infect Ralstonia solanacearum and show common features of ϕKZ-related phages

Virology, 2016
Jumbo phages infecting Ralstonia solanacearum were isolated in Thailand (ϕRSL2) and Japan (ϕRSF1). They were similar regarding virion morphology, genomic arrangement, and host range. Phylogenetic and proteomic tree analyses demonstrate that the ϕRSL2 and ϕRSF1 belong to a group of evolutionary related phages, including Pseudomonas phages ϕKZ, 201ϕ2-1 ...
Bhunchoth, Anjana, Blanc-Mathieu, Romain, Mihara, Tomoko, Nishimura, Yosuke, Askora, Ahmed, Phironrit, Namthip, Leksomboon, Chalida, Chatchawankanphanich, Orawan, Kawasaki, Takeru, Nakano, Miyako, Fujie, Makoto, Ogata, Hiroyuki, Yamada, Takashi   +12 more
openaire   +2 more sources

Novel bacteriophages targeting wheat phyllosphere bacteria carry DNA modifications and single-strand breaks

Virus Research
The phyllosphere microbiome can positively or negatively impact plant health and growth, but we currently lack the tools to control microbiome composition.
Peter Erdmann Dougherty, Maja Schmidt Pedersen, Laura Milena Forero-Junco, Alexander Byth Carstens, Jos M. Raaijmakers, Leise Riber, Lars Hestbjerg Hansen   +6 more
doaj   +1 more source

New Genera and Species of Caulobacter and Brevundimonas Bacteriophages Provide Insights into Phage Genome Evolution

Viruses
Previous studies have identified diverse bacteriophages that infect Caulobacter vibrioides strain CB15 ranging from small RNA phages to four genera of jumbo phages.
Bert Ely, Michael Hils, Aaron Clarke, Maegan Albert, Nadia Holness, Jacob Lenski, Tannaz Mohammadi   +6 more
doaj   +1 more source