Results 161 to 170 of about 6,610 (186)

Jumonji-C domain containing demethylase 1 is critical for heterochromatin organization in Plasmodium falciparum

Gockel J, Wyss M, Singh P, Kanyal A, Keller D, Basson T, Graça B, Rus T, Bryant J, Voss T, Bártfai R.   +10 more
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Inhibitors of Jumonji-C domain-containing histone demethylases

2023
Agencia Estatal de Investigación | Ref.
Sian, Veronica, Souto, José A., Alvarez, Rosana, Nebbioso, Angela, de Lera, Angel R., Altucci, Lucia   +5 more
openaire   +2 more sources

Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase

BioEssays, 2023
AbstractAscorbic acid is a redox regulator in many physiological processes. Besides its antioxidant activity, many intriguing functions of ascorbic acid in the expression of immunoregulatory genes have been suggested. Ascorbic acid acts as a co‐factor for the Fe+2‐containing α‐ketoglutarate‐dependent Jumonji‐C domain‐containing histone demethylases ...
Jeet Maity, Satyabrata Majumder, Ranjana Pal, Bhaskar Saha, Prabir Kumar Mukhopadhyay   +4 more
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Role and regulation of Jumonji C domain-containing histone demethylases 1A and 2B in pulmonary hypertension

4.3 Pulmonary Circulation and Pulmonary Vascular Diseases, 2016
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary vascular cells. Jumonji C domain-containing histone demethylases (JMJDs) are a novel class of epigenetic regulators, implicated in chromatin regulation and often possess the ability to demethylate lysine residues on histones.
Christian Muecke, Swati Dabral, Werner Seeger, Soni Savai Pullamsetti   +3 more
openaire   +1 more source

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.
Shohei, Hamada, Tae-Dong, Kim, Takayoshi, Suzuki, Yukihiro, Itoh, Hiroki, Tsumoto, Hidehiko, Nakagawa, Ralf, Janknecht, Naoki, Miyata   +7 more
openaire   +2 more sources

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors

Journal of Medicinal Chemistry, 2010
Selective inhibitors of Jumonji domain-containing protein (JMJD) histone demethylases are candidate anticancer agents as well as potential tools for elucidating the biological functions of JMJDs. On the basis of the crystal structure of JMJD2A and a homology model of JMJD2C, we designed and prepared a series of hydroxamate analogues bearing a tertiary ...
Shohei, Hamada, Takayoshi, Suzuki, Koshiki, Mino, Koichi, Koseki, Felix, Oehme, Ingo, Flamme, Hiroki, Ozasa, Yukihiro, Itoh, Daisuke, Ogasawara, Haruka, Komaarashi, Aiko, Kato, Hiroki, Tsumoto, Hidehiko, Nakagawa, Makoto, Hasegawa, Ryuzo, Sasaki, Tamio, Mizukami, Naoki, Miyata   +16 more
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Nitric Oxide Modifies Histone Methylation Patterns by Inhibiting Jumonji C Domain Containing Demethylases

Free Radical Biology and Medicine, 2012
Jason R. Hickok, Divya Vasudevan, Douglas D. Thomas   +2 more
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Role and Regulation of Jumonji C domain-containing histone demethylases in Pulmonary Hypertension

Pneumologie, 2016
C Mücke, S Dabral, S Savai Pullamsetti
openaire   +1 more source

High Temperature Triggers Differential Expression of JUMONJI C (JmjC) Domain-Containing Histone Demethylase Genes in Leaf and Stolon Tissues of Potato (Solanum tuberosum L.) Genotypes

Journal of Plant Growth Regulation, 2023
Surbhi Mali, Madhushree Dutta, Komal Goel, Vidhi Raturi, Pravesh Kundu, Ravi Kumar, Vijay Gahlaut, Vishal Acharya, Vijai Kishor Gupta, Salej Sood, Gaurav Zinta   +10 more
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PP-074 INHIBITION OF JUMONJI C DOMAIN CONTAINING HISTONE DEMETHYLASES IN ACUTE MYELOID LEUKEMIA

Leukemia Research, 2014
N. Hastar, D. Koca, Y. Baran
openaire   +1 more source