Results 31 to 40 of about 6,513 (167)

Critical role of histone demethylase Jumonji domain-containing protein 3 in the regulation of neointima formation following vascular injury [PDF]

Cardiovascular Research, 2018
Jumonji domain-containing protein 3 (JMJD3), also called lysine specific demethylase 6B (KDM6b), is an inducible histone demethylase which plays an important role in many biological processes, however, its function in vascular remodelling remains unknown. We aim to demonstrate that JMJD3 mediates vascular neointimal hyperplasia following carotid injury,
XiaoLing, Luo, Di, Yang, WeiJun, Wu, Fen, Long, ChenXi, Xiao, Ming, Qin, Betty YuenKwan, Law, Rinkiko, Suguro, Xin, Xu, LeFeng, Qu, XinHua, Liu, Yi Zhun, Zhu   +11 more
openaire   +2 more sources

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells [PDF]

, 2014
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based
A Albini, A Cock-Rada, A Grigoriadis, An Wouters, AP Mazar, B Castellana, B Grin, B Jayaprakasam, D Hanahan, D Sarrio, Dariusz Ratman, DG Johnson, DR Hurst, ER Hahm, Erik Fransen, F Pereira, F Zambelli, Filip Lardon, G Chiappetta, G Natoli, GK Smyth, Guy Van Camp, H Yu, Ilse M. Beck, J Chia, J Lee, J Lee, JB Mitchem, JH Nijwening, JJ Steffan, JT Thaiparambil, K Belguise, K Miyazaki, Karen Heyninck, Karolien De Bosscher, Katarzyna Szarc vel Szic, KD Brown, Ken Declerck, Ken Op de Beeck, L Dumartin, L Ma, LC Mishra, LP Blair, M Endo, M Kaileh, M Tian, Marc Bracke, MD Edmonds, MJ Duffy, MJ Dunning, MN Ndlovu, N Brunner, N Pouliot, N Widodo, O De Wever, P Chi, PH O'Donnell, PJ Boimel, R Nanda, R Santana-Davila, Rajeev Samant, S Mirza, S Ramadoss, S Subbaram, SC Smith, SD Stan, SD Stan, SL Floor, TW Rockway, W Vanden Berghe, Wim Vanden Berghe, WL Berry, WW Bhat, Y He, YJ Surh   +74 more
core   +7 more sources

Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. [PDF]

PLoS Genetics, 2014
Histone demethylases have emerged as important players in developmental processes. Jumonji domain containing-3 (Jmjd3) has been identified as a key histone demethylase that plays a critical role in the regulation of gene expression; however, the in vivo ...
Qingtian Li, Helen Y Wang, Iouri Chepelev, Qingyuan Zhu, Gang Wei, Keji Zhao, Rong-Fu Wang   +6 more
doaj   +1 more source

Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila [PDF]

, 2017
Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome.
Buszczak, Michael, Eliazer, Susan, Rothenfluh, Adrian, Sayed, Raheel, Scoggin, Shane, Shalaby, Nevine A., Zhang, Qiao   +6 more
core   +1 more source

JMJD5 attenuates oxygen–glucose deprivation and reperfusion‐induced injury in cardiomyocytes through regulation of HIF‐1α‐BNIP3

Kaohsiung Journal of Medical Sciences, 2022
Proteins in Jumonji family function as histone demethylases and participate in cardiac development. Jumonji domain containing 5 (JMJD5) is responsible for the embryonic development through removing methyl moieties from H3K36me2 histone, and has pro ...
Ya‐Nan Zhang, Ya‐Xiang Pang, Da‐Wei Liu, Hai‐Juan Hu, Rui‐Qin Xie, Wei Cui   +5 more
doaj   +1 more source

Epigenetics: new questions on the response to hypoxia [PDF]

, 2011
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke.
Acevedo, Julieta Maria, Perez Perri, Joel Ignacio, Wappner, Pablo   +2 more
core   +3 more sources

Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network. [PDF]

PLoS ONE, 2012
Recent data suggest that the etiology of several metabolic diseases is closely associated with transcriptome alteration by aberrant histone methylation.
Hee-Jin Jun, Jinyoung Kim, Minh-Hien Hoang, Sung-Joon Lee   +3 more
doaj   +1 more source

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Nature Communications, 2019
Jumonji domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod ...
Shuzhi Zheng, Hongmiao Hu, Huimin Ren, Zhenlin Yang, Qi Qiu, Weiwei Qi, Xinye Liu, Xiaomei Chen, Xiekui Cui, Sisi Li, Bing Zhou, Daye Sun, Xiaofeng Cao, Jiamu Du   +13 more
doaj   +1 more source

JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators [PDF]

, 2015
A schematic representation showing the genomic regions of the three genes for ChIP-PCR assay. White box indicates untranslated region, black box indicates coding sequence, line through the box indicates intron region of the genes, lines and numbers above
Jian Zhang, Lei Sun, Lianmeng Liu, Ling Wang, Liyuan Wang, Lu Li, Qiong Rao, Shiwen Huang, Yuxuan Hou   +8 more
core   +7 more sources

Genome-wide analysis of soybean JmjC domain-containing proteins suggests evolutionary conservation following whole-genome duplication

Frontiers in Plant Science, 2016
Histone modifications, such as methylation and demethylation, play an important role in regulating chromatin structure and gene expression. The JmjC domain-containing proteins, an important family of histone lysine demethylases (KDMs), play a key role in
Yapeng Han, Xiangyong Li, Lin Cheng, Yanchun Liu, Hui Wang, Danxia Ke, Hongyu Yuan, Liangsheng Zhang, Lei Wang   +8 more
doaj   +1 more source