Results 41 to 50 of about 6,513 (167)

JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]

, 2016
JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan, Han, Jihong, Li, Luyuan, Luo, Yunping, Ren, Guosheng, Shen, Long, Stupack, Dwayne G, Tan, Xiaoyue, Xiang, Rong, Xun, Jing, Zhang, Yan   +10 more
core   +1 more source

Hypoxia enhances the expression of prostate-specific antigen by modifying the quantity and catalytic activity of Jumonji C domain-containing histone demethylases [PDF]

Carcinogenesis, 2013
Oxygen concentration in prostate cancer tissue is significantly low, i.e. ~0.3% O2. This study showed that pathological hypoxia (
Ho-Youl, Lee, Eun Gyeong, Yang, Hyunsung, Park   +2 more
openaire   +2 more sources

Reprogramming the Epigenome With Vitamin C

Frontiers in Cell and Developmental Biology, 2019
The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs).
Taylor Lee Chong, Emily L. Ahearn, Luisa Cimmino, Luisa Cimmino   +3 more
doaj   +1 more source

Therapeutic Potentials of Inhibition of Jumonji C Domaincontaining Demethylases in Acute Myeloid Leukemia

Turkish Journal of Hematology, 2020
Objective: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression.
Duygu Koca, Nurcan Haştar, Selin Engür, Yağmur Kiraz, Gizem Tuğçe Ulu, Demet Çekdemir, Yusuf Baran   +6 more
doaj   +1 more source

Position-effect variegation revisited: HUSHing up heterochromatin in human cells. [PDF]

, 2016
Much of what we understand about heterochromatin formation in mammals has been extrapolated from forward genetic screens for modifiers of position-effect variegation (PEV) in the fruit fly Drosophila melanogaster.
Lehner, Paul J, Tchasovnikarova, Iva A, Timms, Richard T   +2 more
core   +1 more source

Multitarget Drugs: an Epigenetic Epiphany [PDF]

, 2016
Epigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes.
Atkinson, Baell, Baud, Beckers, Bentley, Blagodatski, Borretto, Bowman, Brand, Burg, Cai, Chen, Chen, Chen, Chen, Ciceri, Dancy, Deans, Fahy, Filippakopoulos, Finley, Fischer, Fuhrmann, Galloway, Gjertsen, Griffith, Guerrant, Guerrant, Hantschel, He, Huang, Hui, Hurley, Jing, Kaniskan, Kingston, Ko, Kortüm, Kozikowski, Lamblin, Lan, Ling, Liu, Lu, Lu, Maes, Mahboobi, Mahboobi, Mai, McGinty, McPherson, Micelli, Moore, Mottamal, Pachaiyappan, Pastor, Patel, Pereira, Pińa, Qian, Rask-Andersen, Rose, Rothbart, Rotili, Saijo, Saijo, Samatar, Schapira, Suganuma, Tavera-Mendoza, Villalba, Wagner, Winter, Wright, Yu, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zuo, Álvarez   +84 more
core   +1 more source

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. [PDF]

, 2020
Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
Choi, Yoon, Nguyen, Hai, SUL, Hei Sook, Viscarra, Jose, Wang, Yuhui   +4 more
core  

Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics

Toxicology Reports, 2014
Background: Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence.
Divya Teja Vavilala, Sujatha Reddy, Sachchidanand, Swami Prakash, V.K. Chaithanya Ponnaluri, Arvind Kumar, Mridul Mukherji   +6 more
doaj   +1 more source

HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

Cellular & Molecular Biology Letters, 2021
Background Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia regulatory protein.
Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang, Weiheng Wen, Weiqiang Jiang, Hong Chen, Donghui Liang, Jia Sun, Ming Wang   +9 more
doaj   +1 more source

Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development [PDF]

, 2018
Background: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3).
A Meissner, A Schedl, AH Monsoro-Burq, AI Agulnik, AJ Bannister, AM Hever, AM Session, Beom-Sik Kang, CB Santos-Rebouças, Chowon Kim, CM Jones, D Meulemans, D Zhang, DJ Montell, Dong-Seok Lee, EL Malloch, FA Mic, FA Seigfried, G Giudetti, G Lupo, G Lupo, G Sun, H Hamada, HB Sarnat, Hyun-Kyung Lee, Hyun-Shik Lee, J Shi, J Xu, Jeen-Woo Park, JR Whetstine, KL Vermillion, Kujin Kwon, LM Kiem, LP Blair, LR Jensen, M O’Donnell, M Rothe, M Scandaglia, M Simoes-Costa, M Tahiliani, M Weider, MD Franco, MD Robinson, MJ Boland, ML Basch, ML Dirksen, MS Mimoto, N Davis-Silberman, N Saint-Germain, ND Hopwood, Oh-Shin Kwon, P Noisa, PH Mathers, PM Kulesa, R Mayor, R Mayor, RD Kortschak, RJ Klose, S Iwase, S Iwase, T Jenuwein, T Kunisada, Tae Joo Park, Taejoon Kwon, Tayaba Ismail, TJ Bailey, W Cizelsky, X Shi, X Yang, Y Aoki, Y Tsukada, Youngeun Jeong, Youni Kim, Z Chen, ZF Chen   +74 more
core   +3 more sources