Results 61 to 70 of about 6,513 (167)

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism [PDF]

, 2014
Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite of enzymes are the 2-oxoglutarate/Fe(II)-dependent dioxygenases (2-ODDs). Cytochromes P450 (CYPs) as often considered the most versatile oxidative enzymes in nature,
Peter J. Facchini, Scott C. Farrow
core   +2 more sources

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1 [PDF]

, 2016
published_or_final_versio
Bai, HJ, Boheler, KR, Chen, DG, Hong, YZ, Lang, JY, Tang, Y, Wu, Q, Yang, HT   +7 more
core   +1 more source

Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory

New Phytologist, Volume 249, Issue 5, Page 2241-2250, March 2026.
Summary Subject to an ever‐changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and integrating these variations to facilitate adaptation.
Rory Osborne
wiley   +1 more source

Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. [PDF]

, 2015
Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells.
Gallipoli, Paolo, Giotopoulos, George, Huntly, Brian JP   +2 more
core   +2 more sources

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B. [PDF]

, 2018
Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical
Al Labban, D., Bongiovanni, M., Dotto, G.P., Jo, S.H., Ostano, P., Panizzon, R., Saglietti, C.   +6 more
core   +2 more sources

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy [PDF]

, 2016
Drawing of Object No ...
Ludovica Morera, Michael Lübbert, Manfred Jung   +2 more
core   +1 more source

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

European Journal of Medicinal Chemistry, 2019
Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences between the histone substrate binding sites in order to improve affinity for the KDM4-subfamily over KDM5 ...
Le Bihan, Yann-Vaï, Lanigan, Rachel M, Atrash, Butrus, McLaughlin, Mark G, Velupillai, Srikannathasan, Malcolm, Andrew G, England, Katherine S, Ruda, Gian Filippo, Mok, N Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M, Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I, Fedorov, Oleg, Brennan, Paul E, Burke, Rosemary, van Montfort, RobL M, Rossanese, Olivia W, Blagg, Julian, Bavetsias, Vassilios   +28 more
openaire   +5 more sources