Results 71 to 80 of about 6,513 (167)

Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Acute myeloid leukaemia (AML) is a genetically heterogeneous malignancy associated with poor prognosis and limited treatment options. To identify molecular programs conserved across AML subtypes and perturbations, we analysed three RNA sequencing datasets that captured venetoclax treatment under metabolic stress and the knockdown of chromatin ...
Muteb Muyey Daniel, Gradel Holel Andwey
wiley   +1 more source

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia [PDF]

, 2013
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options.
A Subramanian, A Tsirigos, AA Mansour, Adolfo A. Ferrando, Alexandros Strikoudis, AM Jankowska, AP Weng, Aristotelis Tsirigos, B King, B Langmead, BG Mar, Bryan King, C Morales Torres, C Simon, C Wang, CG Mullighan, CG Mullighan, Charles G. Mullighan, DI Marks, Elisabeth Paietta, Evangelia Loizou, F Armstrong, F De Santa, G van Haaften, G. Grant Welstead, GG Welstead, Giovanni Tonon, GL Sen, H Wang, Iannis Aifantis, J Zhang, J Zhang, Jacob M. Rowe, Jared Becksfort, Jasper Mullenders, Jelena Nedjic, JK Wang, K Agger, K Chen, K Jepsen, L Espinosa, L Kruidenier, L Wang, Laurens Kruidenier, Linda Holmfeldt, Luyao Xu, M Barradas, Martin S. Tallman, MR Hubner, P Ntziachristos, P Van Vlierberghe, Panagiotis Ntziachristos, Pieter Van Vlierberghe, PJ Valk, Q Li, RA Dickins, Rab Prinjha, RG Verhaak, Rudolf Jaenisch, S Thieme, S Zhong, SB Baylin, Shizuo Akira, SM Kooistra, Sofia Bakogianni, T Palomero, T Satoh, Takashi Satoh, Thomas Trimarchi, VM Sharma, W Zhao, WA Dik, Y Zhang   +72 more
core   +2 more sources

Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Tumour metabolic reprogramming initiates a vicious cycle of immunosuppression and therapy resistance. This synergy disarms immunity and fortifies tumour cells, ultimately driving clonal evolution of resistant disease. Abstract Background Glucose metabolic reprogramming is a hallmark of cancer, best exemplified by the Warburg effect.
Li Ma, Ming‐yang Wu, Cui‐cui Tian, Hao‐ze Shi, Dan Song   +4 more
wiley   +1 more source

Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function [PDF]

, 2013
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is ...
Graaf, P. (Petra) de, Groot Koerkamp, M.J.A. (Marianne), Grosveld, F.G. (Frank), Holstege, F.C.P. (Frank), IJcken, W.F.J. (Wilfred) van, Kaufmann, K. (Kerstin), Leenen, D. (Dik) van, Muiño, J.M. (Jose), Outchkourov, N.S. (Nikolay), Timmers, H.T.M. (Marc)   +9 more
core   +1 more source

The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas

Plant, Cell &Environment, Volume 48, Issue 12, Page 8915-8927, December 2025.
ABSTRACT As essential sources of vegetables, oilseeds, and forage, Brassica crops exhibit complex epigenetic regulation mechanisms involving histone modifications, DNA modifications, RNA modifications, noncoding RNAs, and chromatin remodelling. The agronomic traits and environmental adaptability of crops are regulated by both genetic and epigenetic ...
Daolei Zhang, Yin Lu, Wei Ma, Jianjun Zhao   +3 more
wiley   +1 more source

Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications

Cell Death and Disease
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis.
Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, So Hee Kwon   +4 more
doaj   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara, Gaetano, Carlo, Mai, Antonello, Martelli, Fabio, Spallotta, Francesco, Valente, Sergio, Zeiher, Andreas Michael   +6 more
core   +2 more sources

Overexpression of Tempranillo‐Like Proteins Promotes Dormancy Release in Poplar

Plant, Cell &Environment, Volume 48, Issue 12, Page 9011-9024, December 2025.
ABSTRACT Trees in temperate and boreal latitudes synchronize their growth‐dormancy cycles with seasonal environmental variations to ensure their survival over the years. Dormancy control is crucial during winter when plants cease growth and establish buds to protect their apical meristems from cold temperatures.
Daniela Gómez‐Soto, Paolo Maria Triozzi, Daniel Conde, Cristina del Barrio, Isabel Allona, Mariano Perales   +5 more
wiley   +1 more source

Cellular analysis of the action of epigenetics drugs and probes [PDF]

, 2017
Small molecule drugs and probes are important tools in drug discovery, pharmacology, and cell biology. This is of course also true for epigenetic inhibitors.
A. Ganesan, Edwards AM, Fides Zenk, Gajer (née Wagner) J, Glaser KB, Glaser KB, Jung M, Lynch JT, Maeda T, Manfred Jung, Mirjam Hau, Nicola Iovino, van Lint C   +12 more
core   +1 more source

SWI/SNF chromatin remodeling factor BRAHMA promotes de novo shoot regeneration by epigenetic priming via H3K27me3 removal

The Plant Journal, Volume 124, Issue 5, December 2025.
Significance Statement The chromatin remodeler BRAHMA (BRM) promotes shoot regeneration through epigenetic priming. In callus formation, H3K27me3 at BRM‐primed genes is reduced without transcriptional change, creating a poised state. REF6 and ELF6 demethylases may contribute to this process.
Ayaka Horie, Hikaru Sato, Takuya Sakamoto, Yayoi Inui, Mariana Diaz, Yutaka Suzuki, Sachihiro Matsunaga   +6 more
wiley   +1 more source