Results 61 to 70 of about 251,703 (265)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modeling of Selected Lighting Parameters of LED Panel

Energies, 2020
Semiconductor light sources are currently the fastest growing and most energy efficient group of light sources used in lighting technology. Their lighting parameters, such as luminous flux, correlated color temperature and color rendering index depend on
Krzysztof Baran, Antoni Różowicz, Henryk Wachta, Sebastian Różowicz   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Time-Dependent Optothermal Performance Analysis of a Flexible RGB-W LED Light Engine

Micromachines
The wide application of light emitting diodes (LEDs) in lighting systems has necessitated the inclusion of spectral tunability by using multi-color LED chips.
Md Shafiqul Islam, Mehmet Arik
doaj   +1 more source

Thermal Modeling of GaN HEMT Devices With Diamond Heat-Spreader

IEEE Journal of the Electron Devices Society, 2020
Harvesting the potential performance of GaN-based devices in terms of the areal power density and reliability, relies on the efficiency of their thermal management.
M. Mahrokh, Hongyu Yu, Yuejin Guo
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Active Thermal Control for Thermally Safe Operation of Electric Truck Inverters During Kerbstone Climbing

IEEE Open Journal of Vehicular Technology
Electric trucks are exposed to short-duration high-current events, such as kerbstone climbing, where the traction inverter operates at high current and zero or very low output frequency.
Eneko Agirrezabala, Iosu Aizpuru, David Garrido, Miguel Lajas, Yoann Pascal, Marco Liserre   +5 more
doaj   +1 more source

An online extraction method of junction temperature in IGBT devices with saturation voltage drop

机车电传动, 2023
The junction temperature, working performance, lifespan, and reliability of insulated gate bipolar transistor (IGBT) modules are closely related. Achieving online monitoring of IGBT junction temperature is of great significance to improve the reliability
WANG Zequn, TIAN Xiaoyu, SONG Zhiru, SONG Wensheng   +3 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A simplified junction temperature curve calculation method for IGBT

机车电传动
This paper introduces a simplified junction temperature curve method for insulated gate bipolar transistors (IGBTs), through the utilization of the discrete integral principle. By quantifying junction temperatures within the fundamental wave period, this
LIU Jie, XIE Shunmeng, QI Yu
doaj