Results 61 to 70 of about 252,126 (263)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Active Thermal Control for Thermally Safe Operation of Electric Truck Inverters During Kerbstone Climbing

IEEE Open Journal of Vehicular Technology
Electric trucks are exposed to short-duration high-current events, such as kerbstone climbing, where the traction inverter operates at high current and zero or very low output frequency.
Eneko Agirrezabala, Iosu Aizpuru, David Garrido, Miguel Lajas, Yoann Pascal, Marco Liserre   +5 more
doaj   +1 more source

Life Prediction of Power Devices of Train Traction Inverter Based on SVPWM Modulation

机车电传动, 2021
Space vector pulse width modulation (SVPWM) can be divided into five-segment SVPWM and seven-segment SVPWM. In order to improve the reliability of the traction inverter, the junction temperature analysis and lifetime prediction of the key components of ...
Junhan YE, Ping YANG, Rongbin ZHOU, Xingjiang SHEN, Jun SHEN, Maosen TANG   +5 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Визначення температури напівпровідникової структури тиристора при циклічному навантаженні

Elektrotehnìka ta Elektroenergetika, 2012
Ця стаття присвячена методиці визначення максимального і мінімального значення температури напівпровідникової структури тиристорів випрямлячів, що працюють в режимі циклічно змінного навантаження.
V. S. Ostrenko, O. V. Vasilenko
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A simplified junction temperature curve calculation method for IGBT

机车电传动
This paper introduces a simplified junction temperature curve method for insulated gate bipolar transistors (IGBTs), through the utilization of the discrete integral principle. By quantifying junction temperatures within the fundamental wave period, this
LIU Jie, XIE Shunmeng, QI Yu
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The response of atrioventricular junctional tissue to temperature.

Japanese Circulation Journal, 1994
To determine the optimal temperature for catheter heat mapping without damaging cardiac tissue, we studied the electrophysiologic and histologic responses of the atrioventricular (AV) conduction system exposed to a specific range of temperatures. In 18 closed-chest dogs, an electrode catheter with a thermistor, tip was positioned transvenously at the ...
HIRAO, KENZO, SATO, TADASHI, OTOMO, KENICHIRO, YAMAMOTO, NAOTO, NAWARA, HIROKO, DOSHIDA, NOBUO, SUZUKI, FUMIO, KAWARA, TOKUHIRO, HIEJIMA, KAZUMASA, TANAKA, MICHIO   +9 more
openaire   +3 more sources