Results 71 to 80 of about 4,311,537 (300)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploring the Electro-Thermal Parameters of Reliable Power Modules: Insulated Gate Bipolar Transistor Junction and Case Temperature

Energies, 2018
In the exploration of new energy sources and the search for a path to sustainable development the reliable operation of wind turbines is of great importance to the stability of power systems.
Bo-Ying Liu, Gao-Sheng Wang, Ming-Lang Tseng, Kuo-Jui Wu, Zhi-Gang Li   +4 more
doaj   +1 more source

Junction City Notice of Adopted Amendment (2007-07-02)

, 2007
13 pp. Adopted 2007-07-02. Department of Land Conservation and Development Notice of Adopted AmendmentThe applicant is requesting to rezone property from Exclusive Farm Use in Lane County to General Commercial in Junction City.
Junction City (Or.)
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Time-Dependent Optothermal Performance Analysis of a Flexible RGB-W LED Light Engine

Micromachines
The wide application of light emitting diodes (LEDs) in lighting systems has necessitated the inclusion of spectral tunability by using multi-color LED chips.
Md Shafiqul Islam, Mehmet Arik
doaj   +1 more source

Cave Junction Notice of Adopted Amendment (2007-08-22)

, 2007
11 pp. Adopted 2007-08-22. Department of Land Conservation and Development Notice of Adopted AmendmentAmend zoning map from RR-5 to SR for lot annexed into City of Cave ...
Cave Junction (Or.)
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Active Thermal Control for Thermally Safe Operation of Electric Truck Inverters During Kerbstone Climbing

IEEE Open Journal of Vehicular Technology
Electric trucks are exposed to short-duration high-current events, such as kerbstone climbing, where the traction inverter operates at high current and zero or very low output frequency.
Eneko Agirrezabala, Iosu Aizpuru, David Garrido, Miguel Lajas, Yoann Pascal, Marco Liserre   +5 more
doaj   +1 more source

Life Prediction of Power Devices of Train Traction Inverter Based on SVPWM Modulation

机车电传动, 2021
Space vector pulse width modulation (SVPWM) can be divided into five-segment SVPWM and seven-segment SVPWM. In order to improve the reliability of the traction inverter, the junction temperature analysis and lifetime prediction of the key components of ...
Junhan YE, Ping YANG, Rongbin ZHOU, Xingjiang SHEN, Jun SHEN, Maosen TANG   +5 more
doaj  

Junction City Notice of Adopted Amendment (2008-01-14)

, 2008
29 pp. Adopted 2008-01-14. Department of Land Conservation and Development Notice of Adopted AmendmentAmendments to the Junction City Comprehensive Plan and Zoning Ordinance to establish a process to review annexations, withdrawals, and extraterritoral ...
Junction City (Or.)
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