Results 91 to 100 of about 251,703 (265)

Monitoring Junction Temperature of RF MOSFET under Its Working Condition Using Fiber Bragg Grating. [PDF]

Micromachines (Basel), 2022
Liu Z, Chen N, Liu Y, Chen Z, Pang F, Wang T.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Thermal Management Technology of New-generation High-voltage SiC Devices Applied in Rail Transit Traction System

机车电传动, 2020
The wide band-gap devices represented by SiC are becoming the research focus of power semiconductor devices. The new generation of high-voltage packaging is the main packaging form for high-power SiC devices to cope with high-voltage, heat dissipation ...
Kai HE, Xingzhi WANG, En TIAN, Yanping CHEN, Zechun DOU   +4 more
doaj  

A Technique for Improving the Precision of the Direct Measurement of Junction Temperature in Power Light-Emitting Diodes. [PDF]

Sensors (Basel), 2021
Iero D, Merenda M, Carotenuto R, Pangallo G, Rao S, Brezeanu G, Corte FGD.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Study on Real Time IGBT Junction Temperature Estimation Using the NTC and Calculation of Power Losses in the Automotive Inverter System. [PDF]

Sensors (Basel), 2021
Lim H, Hwang J, Kwon S, Baek H, Uhm J, Lee G.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Fractional Models for Thermal Modeling and Temperature Estimation of a Transistor Junction

Advances in Difference Equations, 2011
The thermal behavior of a power transistor mounted on a dissipator is considered in order to estimate the transistor temperature junction using a measure of the dissipator temperature only. The thermal transfers between the electric power applied to the
Guillemard Franck, Bavoux Bernard, Deletage Jean-Yves, Sabatier Jocelyn, Nguyen HuyCuong, Farges Christophe, Moreau Xavier   +6 more
doaj  

Electro-Thermal Modeling and Thermal Analysis of High-Inertia Synchronous Condenser Converters

Electricity
High-inertia energy storage synchronous condenser (HI-ES-SC) is operated through rotor-excited variable-speed mechanisms to provide grid power support. Power devices are exposed to alternating electro-thermal stresses, with significant implications for ...
Jinxin Ouyang, Yaowei Lin, Zhiqi Ye, Yanbo Diao   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source