Results 91 to 100 of about 4,311,537 (300)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An online extraction method of junction temperature in IGBT devices with saturation voltage drop
机车电传动, 2023 The junction temperature, working performance, lifespan, and reliability of insulated gate bipolar transistor (IGBT) modules are closely related. Achieving online monitoring of IGBT junction temperature is of great significance to improve the reliability
WANG Zequn +3 more
doaj
, 2018 junction bed files generated by regtools junctions ...
Haiwang Yang (5008385)
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Визначення температури напівпровідникової структури тиристора при циклічному навантаженні
Elektrotehnìka ta Elektroenergetika, 2012 Ця стаття присвячена методиці визначення максимального і мінімального значення температури напівпровідникової структури тиристорів випрямлячів, що працюють в режимі циклічно змінного навантаження.
V. S. Ostrenko, O. V. Vasilenko
doaj +1 more source
Junction-temperature measurement of IMPATT diodes
Electronics Letters, 1972 The breakdown voltage VB of an IMPATT diode is a function of the junction temperature. Pulse techniques are applied to measure VB directly during actual operation, thus giving the temperature within an accuracy of a few per cent. The method also provides a display of 'space-charge resistance at the operating temperature.
N.D. Kenyon, F.J. D'Alessio
openaire +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Remote temperature mapping of high-power InGaN/GaN MQW flip-chip design LEDs [PDF]
, 2005 We report on the study of heat 2D-distribution in InGaN LEDs with the stress made on local device overheating and temperature gradients inside the structure.
Zakheіm А. L. +3 more
core +1 more source