Results 171 to 180 of about 5,614 (215)

Junin Virus Vaccines

2002
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus (JUN), was isolated in 1958 (Parodi et al. 1958; Piroski et al. 1959).
D A, Enria, J G, Barrera Oro
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Actions of Complement on Junin Virus

Clinical Infectious Diseases, 1989
Fresh sera from normal rhesus monkeys, guinea pigs, and rabbits inactivated 90%-99% of the infectivity of Vero cell-passaged, attenuated strains of Junin virus (JV) within 60 minutes. Selective depletion studies showed that inactivation occurred by the classical complement pathway. Complement had little effect on virulent JV strains.
R H, Kenyon, C J, Peters
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Characteristics of Junin Virus

Archiv f�r die gesamte Virusforschung, 1966
1. There is a linear relationship between the log dose of Junin virus inoculated in guinea pigs and the mean reciprocal time of death. 2. The decrease of infectivity is not significant when the virus is kept for 26 hours at 25° C or six hours at 37° C; but the inactivation is practically complete after 192 hours at 4° C, 72 hours at 25 ...
A S, Parodi, C E, Coto, M, Boxaca, S, Lajmanovich, S, González   +4 more
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Susceptible adult murine model for Junin virus

Journal of Medical Virology, 1988
AbstractThe adult mouse model had been considered resistant to Junin virus (JV) infection. However, we found that C3H/HeJ murine strain proved highly susceptible up to 5 months of age to intracerebral inoculation with the prototype XJ JV strain, showing neurological signs and 80–90% mortality within 13 days. Neutralizing antibodies (Nt Ab) were absent,
O E, Campetella, N V, Galassi, N, Sanjuan, H A, Barrios   +3 more
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Novel neutralizing monoclonal antibodies against Junin virus

Antiviral Research, 2018
Junin virus (JUNV) is the pathogen of Argentine haemorrhagic fever which results in high lethality, while there is limited therapeutics available. Here, a series of mouse monoclonal antibodies (mAbs) were isolated through immunization with DNA and screening against glycoprotein complex (GPC). Finally, five mAbs were found to effectively neutralize JUNV.
Xiaoyan Pan, Yan Wu, Wei Wang, Leike Zhang, Gengfu Xiao   +4 more
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Attenuated Junin virus infection in callithrix jacchus

Journal of Medical Virology, 1985
AbstractTwenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID50 of the attenuated XJCl3 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420‐day period.
M M, Avila, M J, Frigerio, E L, Weber, S, Rondinone, S R, Samoilovich, R P, Laguens, L B, de Guerrero, M C, Weissenbacher   +7 more
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Genetic Variation in Junin Virus

1993
Junin virus (JV) is a member of Arenaviridae able to cause a severe disease in humans known as Argentine hemorrhagic fever (AHF). The first isolation of this agent was performed in 1958 by Parodi et al. from a human case. Epidemics of AHF have occurred each year in the central area of the country, with incidence peaks coincident with harvest time of ...
Celia E. Coto, Elsa B. Damonte, Laura E. Alche, Luis Scolaro   +3 more
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Ribavirin effect on experimental Junin virus‐induced encephalitis

Journal of Medical Virology, 1988
AbstractJunin virus, the etiological agent of Argentine hemorrhagic fever, produces in man a disease mainly characterized by hemorrhagic alterations, commonly accompanied by neurological symptoms, and leading to 10% mortality. Intracerebral inoculation in 10‐day‐old rats or intraperitoneal inoculation in 2‐day‐old rats leads to high mortality due to ...
M C, Remesar, J L, Blejer, M C, Weissenbacher, M R, Nejamkis   +3 more
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Endothelial cell function alteration after Junin virus infection

Thrombosis and Haemostasis, 2003
SummaryHematologic involvement is the main feature of Argentine hemorrhagic fever (AHF), an endemo-epidemic disease caused by Junin virus (JV). Since endothelial dysfunction could play a role in AHF-altered hemostasis, we studied human umbilical vein endothelial cell (HUVEC) infection with a virulent (JVv) and a non-virulent (JVa) JV strain. Cells were
Ricardo Martin, Gomez, Roberto Gabriel, Pozner, Maria Angela, Lazzari, Lina Paola, D'Atri, Soledad, Negrotto, Ana Marisa, Chudzinski-Tavassi, María Isabel, Berría, Mirta, Schattner   +7 more
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Formalin inactivated junin virus: Immunogenicity and protection assays

Journal of Medical Virology, 1989
AbstractThe aim of this study was to determine if Junin virus inactivated with formalin (FA) was immunogenic and able to elicit a protective response in the guinea pig. The XJ‐Clone 3 strain of Junin virus grown in Vero cells was exposed to FA at 0°C.
C, Videla, G, Carballal, P, Remorini, J, La Torre   +3 more
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