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The Met1-Ub System in T Cells: What We Know, What We Think We Know. [PDF]
Rizk J, Gyrd-Hansen M.
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Protocol to establish endogenous knockins in Jurkat T-ALL cells using CRISPR-Cas9-mediated homology-directed repair. [PDF]
Costa JR +10 more
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Efficient discovery of an agonistic anti-OX40 nanobody by epitope-directed approach to address enrichment-driven epitope bias. [PDF]
Iemura T +10 more
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NETs drive CD4⁺ T cell dysfunction in sepsis via mitochondrial ROS and impaired calcium signalling. [PDF]
Li H +15 more
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Dual impact of EZH1/2-targeted therapy in HTLV-1-associated inflammation: Direct and indirect mechanisms. [PDF]
Zou Y +5 more
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A tumor suppressor role of the miR-15b/16-2 cluster in T-cell acute lymphoblastic leukemia.
Toribio ML +8 more
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Jurkat T Cells and Development of the T-Cell Receptor Signalling Paradigm
Nature Reviews Immunology, 2004Twenty years of investigation have yielded a detailed view of the signalling machinery engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling came from studies carried out with transformed T-cell lines. Perhaps the best known of these model systems is the Jurkat leukaemic T-cell line, and here we review some of the key
Robert T Abraham
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