Results 171 to 180 of about 43,474 (209)

Effects of benzo(a)pyrene on protein expression in Jurkat T‐cells

PROTEOMICS, 2004
AbstractPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants of air, water and soil, and are produced by the incomplete combustion of organic materials. The International Agency for Research on Cancer has characterized PAHs as carcinogens. In this study, we investigated the effects of benzo(a)pyrene (B(a)P), which is the most
Sangnam, Oh, Hosub, Im, Eunha, Oh, Joohyun, Lee, Jin-Young, Khim, Joohee, Mun, Yanghee, Kim, Eunil, Lee, Joon, Kim, Donggeun, Sul   +9 more
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Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells

Prostaglandins & Other Lipid Mediators, 2007
We investigated the effects of serum on lysophospholipid-induced cytotoxicity in Jurkat T cells. We found that sphingosylphosphorylcholine (SPC, also known as lysosphingomyelin) induced cytotoxicity and that albumin in serum could protect cells by binding directly to SPC. Furthermore, we also found that SPC induced ROS generation, increased [Ca(2+)](i),
Mijin, Han, Yu-Lee, Kim, Santosh J, Sacket, Kyeok, Kim, Hyo-Lim, Kim, Ji-Yeong, Jo, Nam-Chul, Ha, Dong-Soon, Im   +7 more
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Oxygen radical generation and endosulfan toxicity in Jurkat T-cells

Molecular and Cellular Biochemistry, 2003
The mechanism by which endosulfan exposure causes cellular dysfunction in experimental animals and humans is not clear. In the present study, we provide experimental evidence in support of the role of oxidative stress in endosulfan toxicity. Using both cell free system and Jurkat cells as in vitro models, we demonstrate that endosulfan can generate ...
Krishnaswamy, Kannan, Sushil K, Jain
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p38/SAPK2-Dependent Gene Expression in Jurkat T Cells

Biological Chemistry, 2000
The stress-activated protein kinase p38/SAPK2 is known to regulate the activity of transcription factors and to control expression of several genes at the transcriptional or post-transcriptional level. In order to identify genes whose expression is under the control of p38/SAPK2 activity, we have compared the mRNA levels of a pattern of 588 genes ...
M, Rolli-Derkinderen, M, Gaestel
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Cruciferous phytoalexins: antiproliferative effects in T-Jurkat leukemic cells

Leukemia Research, 2005
We tested antiproliferative activity of selected cruciferous phytoalexins including brassinin, 1-methoxybrassinin, (+/-)-spirobrassin, (+/-)-1-methoxyspirobrassinin and (+/-)-1-methoxyspirobrassinol, in leukemic Jurkat cell. The most effective of the tested phytoalexins was 1-methoxybrassinin with IC(50) 10 micromol l(-1).
M, Pilátová, M, Sarisský, P, Kutschy, A, Mirossay, R, Mezencev, Z, Curillová, M, Suchý, K, Monde, L, Mirossay, J, Mojzis   +9 more
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Characterization of Galectin-9-Induced Death of Jurkat T Cells

Journal of Biochemistry, 2006
Galectin-9, a mammalian lectin with affinity for beta-galactosides, is known as an apoptosis inducer of activated T lymphocytes. In the present study, we examined the properties of galectin-9-mediated cell death of Jurkat T cells. Galectin-9NC (wild-type), consisting of two CRDs (N-terminal and C-terminal carbohydrate recognition domains), and ...
Liang-Hao, Lu, Ryusuke, Nakagawa, Yumiko, Kashio, Aiko, Ito, Hiroki, Shoji, Nozomu, Nishi, Mitsuomi, Hirashima, Akira, Yamauchi, Takanori, Nakamura   +8 more
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Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

Molecular Pharmacology, 2006
Peripheral benzodiazepine receptor (PBR) has been considered a promising drug target for cancer therapy, and several ligands have been developed for this purpose. Human T-lymphoma Jurkat cells have been considered as lacking PBR and are often used as negative control to prove the specificity of PBR ligands effects.
COSTA, BARBARA, SALVETTI, ALESSANDRA, ROSSI, LEONARDO, SPINETTI F, LENA A, CHELLI B, RECHICHI M, DA POZZO, ELEONORA, GREMIGNI, VITTORIO, MARTINI, CLAUDIA   +9 more
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Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins

Pharmacological Reports, 2013
Recent studies have shown that anisomycin significantly inhibits mammalian cell proliferation, but its mechanism remains unclear. In this study, Jurkat T cells were used to first explore a relationship between effect of anisomycin on them and alteration of cell cycle-regulating proteins.Cell colony formation, CCK-8 assay, flow cytometry, RT-PCR and ...
Chunyan, Yu, Feiyue, Xing, Zhengle, Tang, Christian, Bronner, Xijian, Lu, Jingfang, Di, Shan, Zeng, Jing, Liu   +7 more
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[THE INDUCTION OF CD25 EXPRESSION IN Jurkat T CELLS].

Tsitologiia, 2015
The expression of an α-subunit of interleukin-2 receptor (IL-2Rα) was assessed by quantifying activation-induced upregulation of CD25 in IL-2-independent Jurkat leukemic cell line. It has been found that in growing Jurkat culture within 24 h, phytohemagglutinin (PHA, 5 μg/ml) or PHA in combination with 12,13-phorbol dibutirate (PDBu, 10(-8)M) increase ...
A N, Shatrova, E V, Mityushova, N V, Aksenov, L L, Marakhova   +3 more
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Echinacea alkylamides inhibit interleukin-2 production by Jurkat T cells

International Immunopharmacology, 2006
Alkylamides present in Echinacea species have reported immunomodulatory actions, yet their direct effects on T lymphocytes, key mediators of antiviral immunity, are poorly understood. We hypothesized that constituents present in ethanolic extracts of Echinacea species exert direct immunomodulatory effects on human Jurkat T cells.
Masa, Sasagawa, Nadja B, Cech, Dean E, Gray, Gary W, Elmer, Cynthia A, Wenner   +4 more
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