Results 161 to 170 of about 43,474 (209)
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Mechanism of Thiazolidinedione-Dependent Cell Death in Jurkat T Cells
Molecular Pharmacology, 2007Thiazolidinediones are synthetic agonists for the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) and are therapeutically used as insulin sensitizers. Besides therapeutical benefits, potential side effects such as the induction of cell death by thiazolidinediones deserve consideration. Although PPARgamma-dependent and -
Mathias, Soller +4 more
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Models of Anergy in the Human Jurkat T Cell Line
ASSAY and Drug Development Technologies, 2003We investigated two model systems to study anergy in a human T cell line. OKT3 or calcium ionophore stimulation of Jurkat cells, in the absence of costimulation, resulted in a steep reduction in the transcription and secretion of IL-2 in response to subsequent stimulation via CD3 and CD28.
Christopher J, Howe +5 more
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Calmodulin regulation of Ca2+ entry in Jurkat T cells
Cell Calcium, 1998We have previously proposed a role for calmodulin (CaM) in the regulation of initiation of Ca2+ entry in Jurkat T cells, as well as in the regulation of the current that mediates Ca2+ entry, IT. In this report, we provide evidence for the mechanism of CaM action.
D M, Haverstick +2 more
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Effect of lysophospholipids on signaling in the human Jurkat T cell line
Journal of Cellular Physiology, 1995AbstractLysophospholipids have recently been demonstrated to induce activation and proliferation of fibroblasts and other cell lineages by interacting with high affinity cell surface receptors leading to specific intracellular signaling events. Platelet activation, likely at the site of injury or inflammation, results in increased production of ...
Y, Xu, G, Casey, G B, Mills
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Transfection of Jurkat T cells by droplet electroporation
Biochemical Engineering Journal, 2017Abstract A droplet electroporation system has been successfully demonstrated for transfection of Jurkat T cell with much higher transfection efficiency (66%) than that of conventional system (11.4%) with the advantages of superior cell viability, comparable throughput, and user-friendly interface.
Do Jin Im, Su-Nam Jeong
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Adhesion‐dependent modulation of actin dynamics in Jurkat T cells
Cytoskeleton, 2013Contact formation of T cells with antigen presenting cells results in the engagement of T cell receptors (TCRs), recruitment and aggregation of signaling proteins into microclusters and ultimately, T cell activation. During this process, T cells undergo dramatic changes in cell shape and reorganization of the cytoskeleton.
King, Lam Hui +2 more
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Covalent binding of non-proteolysed C3 to Jurkat T cells
Molecular Immunology, 1991Purified C3 binds covalently to Jurkat T cells upon incubation at neutral pH. This binding does not appear to involve proteolysis of C3; it leads to high-molecular-weight associations, preferentially through ester linkages, which are disrupted upon incubation with hydroxylamine at alkaline pH.
C D, Barro, C L, Villiers, M G, Colomb
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Effect of Polyamine Analogues on Hypusine Content in JURKAT T-Cells
Journal of Medicinal Chemistry, 1998The availability of synthetic hypusine and deoxyhypusine has made it possible to develop analytical methods which allow for the measurement of these compounds in various tissues. The methods involve dansylation of extracts from the pellet remaining after perchloric acid precipitation of cell or tissue homogenates, followed by high-performance liquid ...
R J, Bergeron +6 more
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Malondialdehyde production in Jurkat T cells subjected to oxidative stress
Nutrition, 2003We investigated the relation between membrane lipid peroxidation, as evaluated by malondialdehyde (MDA), and oxidative stimuli in the Jurkat T-cell line and designed a cellular model to assess the antioxidant potential of compounds.Jurkat T cells were subjected to different concentrations of Fe(2+) ions (from 25 to 150 micromol/L) or H(2)O(2) (from 0.1
D.Erba +3 more
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Expression of the Tn antigen on T-lymphoid cell line Jurkat
Biochemical and Biophysical Research Communications, 1991Expression of the Tn antigen on a T-lymphoid cell line, Jurkat, was investigated using an anti-Tn monoclonal antibody, MLS 128. Immunoprecipitation or immunoaffinity chromatography of a lysate of Jurkat cells led to the isolation of a 120 kDa glycoprotein carrying the Tn antigen.
H, Nakada +6 more
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