Results 51 to 60 of about 43,474 (209)

Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment

Frontiers in Immunology
IntroductionFollowing the approval of Chimeric Antigen Receptor T-cell Immunotherapy(CAR-T) in multiple countries, the Food and Drug Administration (FDA) approved tumor-infiltrating lymphocytes (TILs) and T-cell receptor-engineered T cells (TCR-T ...
Zhaoyi Wang, Zhongqi Diao, Yiyan Zhang, Jiangying Liu, Yeshan Li, Zijin Sun, Huimin Zhen, Haojia Wang, Siyun Yang, Tieshan Wang, Lei Ni   +10 more
doaj   +1 more source

Cytoskeletal forces during signaling activation in Jurkat T-cells

Molecular Biology of the Cell, 2015
T-cells are critical for the adaptive immune response in the body. The binding of the T-cell receptor (TCR) with antigen on the surface of antigen-presenting cells leads to cell spreading and signaling activation. The underlying mechanism of signaling activation is not completely understood.
Hui, King Lam, Balagopalan, Lakshmi, Samelson, Lawrence E., Upadhyaya, Arpita   +3 more
openaire   +2 more sources

Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells [PDF]

Bioorganic & Medicinal Chemistry, 2014
Thujaplicins are tropolone-derived natural products with antiproliferative properties. We recently reported that certain tropolones potently and selectively target histone deacetylases (HDAC) and inhibit the growth of hematological cell lines. Here, we investigated the mechanisms by which these compounds exert their antiproliferative activity in ...
Sophia N, Ononye, Michael D, Vanheyst, Charles, Giardina, Dennis L, Wright, Amy C, Anderson   +4 more
openaire   +2 more sources

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Targeting Jurkat T Lymphocyte Leukemia Cells by an Engineered Interferon-Alpha Hybrid Molecule

Cellular Physiology and Biochemistry, 2017
Background/Aims: Adult T-cell leukemia/lymphoma (ATL) is a very aggressive T cell malignancy that carries a poor prognosis, primarily due to its resistance to chemotherapy and to life-threatening infectious complications. Interferon-alpha (IFNα) has been
Dehai Yu, Zhonghua Du, Wei Li, Huaqiu Chen, Songgen Ye, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu   +7 more
doaj   +1 more source

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase

Journal of Lipid Research, 2018
PUFAs are important constituents of membrane glycerophospholipids. However, changes in the capacities to incorporate and metabolize PUFAs when cells enter the cell cycle have not been thoroughly studied.
Philippe-Pierre Robichaud, Jean Eric Munganyiki, Eric Boilard, Marc E. Surette   +3 more
doaj   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie International Edition, Volume 65, Issue 44, 26 October 2026.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources

Cell-Cycle-Dependent Regulation of Ca2+-Activated K+ Channel in Jurkat T-Lymphocyte

Journal of Pharmacological Sciences, 2007
Small-conductance Ca2+-activated K+ (SK2) channel plays an important role in the activation of Jurkat T-lymphocytes by maintaining electrical gradients for the sustained Ca2+ influx. Apamin-sensitive K+ current was significantly decreased with cell-cycle
Takashi Morimoto, Susumu Ohya, Hidetoshi Hayashi, Kikuo Onozaki, Yuji Imaizumi   +4 more
doaj   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source