Results 31 to 40 of about 43,474 (209)

13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3.

PLoS ONE, 2013
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid purified from soy fermentation products, induces apoptosis in human cancer cells. We investigated the inhibitory effects and mechanism of action of 13-MTD on T-cell non-Hodgkin's
Qingqing Cai, Huiqiang Huang, Dong Qian, Kailin Chen, Junhua Luo, Ying Tian, Tianxin Lin, Tongyu Lin   +7 more
doaj   +1 more source

Expression and role of microRNA-663b in childhood acute lymphocytic leukemia and its mechanism

Open Medicine, 2019
Recent studies have shown that microRNAs (miRNAs) play a key role in various malignant tumors. MiR-663b has been found to have important roles in several cancers, however, the role of miR-663b in T cell acute lymphocytic leukemia (T-ALL) remains unclear.
Liu Xuehua, Zhang Haixia, Zhang Baorong, Zhang Xiaohong   +3 more
doaj   +1 more source

Association of TIM-3 expression with glucose metabolism in Jurkat T cells [PDF]

BMC Immunology, 2020
Abstract Background T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation and leads to insufficient immunity in cancer and chronic infection.
Mi Jin Lee, Su Jin Yun, Bokyoung Lee, Eun Jeong, Gyesoon Yoon, Kyongmin Kim, Sun Park   +6 more
openaire   +3 more sources

Regulation of galectin-9 expression and release in Jurkat T cell line cells [PDF]

Glycobiology, 2002
Ecalectin/galectin-9 was recently described as a novel eosinophil chemoattractant highly expressed in immune tissues. We investigated the regulation of galectin-9 expression and release in Jurkat (a T cell line) cells. We demonstrated that medium and long-sized galectin-9 isoforms were constitutively expressed, and phorbol 12-myriastate 13-acetate (PMA)
Sophie, Chabot, Yumiko, Kashio, Masako, Seki, Yukako, Shirato, Kazuhiro, Nakamura, Nozomu, Nishi, Takanori, Nakamura, Ryoji, Matsumoto, Mitsuomi, Hirashima   +8 more
openaire   +2 more sources

The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis

Arthritis Research & Therapy, 2017
Background Tumor necrosis factor-alpha (TNF-α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types.
Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu   +5 more
doaj   +1 more source

Analyzing Jurkat T Cell Viability and T Cell Receptor Signaling in Tumor Microenvironments

Midwestern Journal of Undergraduate Sciences, 2022
The immune system is responsible not only for protection against foreign invaders (e.g., viruses and bacteria) but also against abnormal cell growth (e.g., cancer). Although the initiating causes of cancer are wide-ranging, one universal characteristic common to all is that healthy cells mutate in ways that dysregulate their growth and survival ...
Rylee Hanson, Jack Treml Jack Treml, Randall Logan   +2 more
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes. [PDF]

PLoS ONE, 2017
Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does not halt the autoimmune process; therefore, development of immunotherapies aiming to preserve ...
Valentina Perri, Marsha Pellegrino, Francesca Ceccacci, Anita Scipioni, Stefania Petrini, Elena Gianchecchi, Anna Lo Russo, Serena De Santis, Giovanna Mancini, Alessandra Fierabracci   +9 more
doaj   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Inhibition of death-ligand-induced apoptosis in Epstein-Barr virus-encoded small RNAs-expressing human T-cell line

Infectious Agents and Cancer
Background In chronic active Epstein-Barr virus (EBV) (CAEBV) disease, EBV infects T or natural killer (NK) cells, and patients frequently exhibit a broad spectrum of EBV-associated T/NK-cell lymphoproliferative disorders including polyclonal ...
Yuki Matsumoto, Ayako Tateishi, Hiroyuki Kanno   +2 more
doaj   +1 more source