Results 21 to 30 of about 43,474 (209)

Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells

BMC Molecular and Cell Biology, 2022
Background The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell receptor signalling as well as actin polymerisation.
Aussanee Nuiyen, Araya Rattanasri, Piyamaporn Wipa, Sittiruk Roytrakul, Apirath Wangteeraprasert, Sutatip Pongcharoen, Jutaporn Ngoenkam   +6 more
doaj   +1 more source

Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells. [PDF]

PLoS ONE, 2009
BACKGROUND: Human T cells play an important role in pathogen clearance, but their aberrant activation is also linked to numerous diseases. T cells are activated by the concurrent induction of the T cell receptor (TCR) and one or more costimulatory ...
Rebekah R Bartelt, Noemi Cruz-Orcutt, Michaela Collins, Jon C D Houtman   +3 more
doaj   +1 more source

Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells

Journal of Hematology & Oncology, 2018
Background Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug resistance to chemotherapy remains a significant clinical problem.
Jiancheng Wang, Xin Liu, Yuan Qiu, Yue Shi, Jianye Cai, Boyan Wang, Xiaoyue Wei, Qiong Ke, Xin Sui, Yi Wang, Yinong Huang, Hongyu Li, Tao Wang, Ren Lin, Qifa Liu, Andy Peng Xiang   +15 more
doaj   +1 more source

Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism

Cellular & Molecular Biology Letters, 2022
Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous death (ACAD).
Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung, Guang-Yaw Liu   +7 more
doaj   +1 more source

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation. [PDF]

Adv Sci (Weinh)
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Lu T, Nikolić M, Huang B, Punj D, De Keersmaecker H, Van Acker T, Xie W, Vanlauwe F, Blondeel P, De Graeve L, Sauvage F, Xiong R, Huang C, Vanhaecke F, Braeckmans K, De Smedt SC.   +15 more
europepmc   +2 more sources

Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor [PDF]

Iranian Biomedical Journal, 2020
Background: Recently, modification of T cells with chimeric antigen receptor (CAR) has been an attractive approach for adoptive immunotherapy of cancers. Typically, CARs contain a single-chain variable domain fragment (scFv).
Mahmoud Hassani, Fatemeh Hajari Taheri, Zahra Sharifzadeh, Arash Arashkia, Jamshid Hadjati, Wytske M. van Weerden, Shahriyar Abdoli, Mohammad Hossein Modarressi, Mohsen Abolhassani   +8 more
doaj   +2 more sources

Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells [PDF]

Biological Research, 2004
We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 microg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity.
VERSTRAETEN, SANDRA V., OTEIZA, PATRICIA I., FRAGA, CÉSAR G.   +2 more
openaire   +4 more sources

Inhibition of phosphatidylserine synthesis in Jurkat T cells by hydrogen peroxide

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001
Incubation of Jurkat cells in the presence of H2O2 either directly added to the culture medium or generated with glucose oxidase, menadione or the couple xanthine/xanthine oxidase induced a marked decrease of phosphatidylserine synthesis in the absence of changes in the synthesis of phosphatidylcholine and phosphatidylethanolamine.
Pelassy, Claudette, Breittmayer, Jean Philippe, Aussel, Claude   +2 more
openaire   +2 more sources

Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL) [PDF]

BioImpacts
Introduction: The PI3K/AKT/mTOR signaling pathway plays a significant role in the development of T-cell acute lymphoblastic leukemia (T-ALL). Rapamycin is a potential therapeutic strategy for hematological malignancies due to its ability to suppress mTOR
Fateme Arjmand, Samaneh Shojaei, Mitra Khalili, Hossein Dinmohammadi, Behzad Poopak, Samira Mohammadi-Yeganeh, Yousef Mortazavi   +6 more
doaj   +1 more source

Inhibition of Kv1.3 Channels in Human Jurkat T Cells by Xanthohumol and Isoxanthohumol [PDF]

The Journal of Membrane Biology, 2015
Using whole-cell patch-clamp technique, we investigated influence of selected compounds from groups of prenylated chalcones and flavonoids: xanthohumol and isoxanthohumol on the activity of Kv1.3 channels in human leukemic Jurkat T cells. Obtained results provide evidence that both examined compounds were inhibitors of Kv1.3 channels in these cells ...
Gąsiorowska, Justyna, Teisseyre, Andrzej, Uryga, Anna, Michalak, Krystyna   +3 more
openaire   +2 more sources