Results 11 to 20 of about 43,474 (209)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription. [PDF]

FEBS Open Bio
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Wang L, Deng M, He D, Lai D, Liu D, Zhu D, Zhang Z, Tang P, Zhou C, Yin M, Bao X.   +10 more
europepmc   +2 more sources

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo. [PDF]

Adv Sci (Weinh)
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Li M, Lyu J, Li K, Dravid A, Balasubramani D, K Ashkezari AH, Choi HK, Kwong GA, Singh A, Zhu C.   +9 more
europepmc   +2 more sources

Regulation of the Association of p120 with Grb2 in Jurkat T Cells [PDF]

Journal of Biological Chemistry, 1996
The c-cbl protooncogene product (p120(cbl)) is a known substrate of multiple tyrosine kinases. It is found in complexes with critical signal transduction molecules, including the linker protein Grb2. Here, we demonstrate using an immobilized Grb2-binding peptide that the Grb2-p120(cbl) complex dissociates in vivo following engagement of the T-cell ...
J A, Donovan, Y, Ota, W Y, Langdon, L E, Samelson   +3 more
openaire   +2 more sources

Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells [PDF]

British Journal of Cancer, 2002
Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h following induction of apoptosis.
Al-Saffar, NMS, Titley, JC, Robertson, D, Clarke, PA, Jackson, LE, Leach, MO, Ronen, SM   +6 more
openaire   +4 more sources

T cell activation and effector function in the human Jurkat T cell model

, 2023
In order to understand T cell function, it is necessary to completely decipher the molecular dynamics underlying T cell activation and effector function. In vitro easy-to-handle cellular models are valuable tools to study intracellular molecular mechanisms in live cells.
Carrasco Padilla, C, Aguilar Sopeña, O, Gómez Morón, Alvaro, Alegre Gómez, Sergio, Sánchez Madrid, Francisco, Martín Cófreces, Noa Beatriz, Roda Navarro, Pedro   +6 more
openaire   +3 more sources

Involvement of calpain in the process of Jurkat T cell chemotaxis [PDF]

Journal of Neuroscience Research, 2008
AbstractMassive T cell infiltration into the central nervous system is a hallmark of multiple sclerosis (MS) and its rodent model experimental autoimmune encephalomyelitis (EAE), resulting in the induction of many of the pathophysiological events that lead to neuroinflammation and neurodegeneration.
Jonathan T, Butler, Supriti, Samantaray, Craig C, Beeson, Swapan K, Ray, Naren L, Banik   +4 more
openaire   +2 more sources

GABAA receptor plasticity in Jurkat T cells

Biochimie, 2013
GABAA receptors (GABAAR) mediate inhibitory neurotransmission in the human brain. Neurons modify subunit expression, cellular distribution and function of GABAAR in response to different stimuli, a process named plasticity. Human lymphocytes have a functional neuronal-like GABAergic system with GABAAR acting as inhibitors of proliferation.
Dionisio, Leonardo Raul, Arias, Verònica Cecilia, Bouzat, Cecilia Beatriz, Esandi, María del Carmen   +3 more
openaire   +3 more sources

Antiproliferative Activity ofT. welwitschiiExtract on Jurkat T CellsIn Vitro [PDF]

BioMed Research International, 2015
Triumfetta welwitschiiis a plant used traditionally for the treatment of fever and diarrhoea. Previous work has shown thatT. welwitschiihas antibacterial activity. The purpose of this study was to investigateT. welwitschiiextract for anticancer activity against Jurkat T cells. The Jurkat T cell line is used to study acute T cell leukaemia.
Batanai Moyo, Stanley Mukanganyama
openaire   +2 more sources

Overexpression of MicroRNA-506 in Jurkat (acute T Cell Leukemia) Cell Line [PDF]

Iranian Journal of Pathology, 2020
Acute lymphoblastic leukemia (ALL) is a malignant disease that arises from various mutations in B or T-lymphoid progenitors. MicroRNAs (miRNAs) regulate gene expression by binding to the 3' untranslated region of protein-coding genes. Dysregulation of miRNA expression may result in the development of cancerous phenotypes.
Yasuj, S.R, Obeidi, N, Khamisipour, G, Gharehdaghi, Z, Zangeneh, Z   +4 more
openaire   +2 more sources

Effects of Fludioxonil on the Cell Growth and Apoptosis in T and B Lymphocytes

Biomolecules, 2019
Fludioxonil is fungicide used in agriculture, which is present in fruits and vegetables. In this study, the effects of fludioxonil on human immune cell viability, apoptosis, cell cycle arrest, and mitochondrial membrane potential were examined in human ...
Gun-Hwi Lee, Kyung-A Hwang, Kyung-Chul Choi   +2 more
doaj   +1 more source